SSR1 - signal sequence receptor subunit 1 Gene

Also Known as TRAPA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6745

About SSR1

Cytogenetic location: 6p24.3 Genomic coordinates (GRCh38): 6:7,281,143-7,313,199 (from NCBI)

This gene has 11 transcripts (splice variants) and 235 orthologues. Ubiquitous expression in thyroid (RPKM 19.2), appendix (RPKM 16.5) and 25 other tissues.

Summary

The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein encoded by this gene and a 22-kD glycoprotein. This gene generates several mRNA species as a result of complex alternative polyadenylation. This gene is unusual in that it utilizes arrays of polyA signal sequences that are mostly non-canonical. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

SSR1 Products (2)

mRNA Protein Name
NM_001292008.2 NP_001278937.1 translocon-associated protein subunit alpha isoform 2 precursor
NM_003144.5 NP_003135.2 translocon-associated protein subunit alpha isoform 1 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
17380188 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SSR1 Protein Structure

TRAP_alpha

TRAP_alpha: Translocon-associated protein (TRAP), alpha subunit (1 - 285)

  • 0
  • 100
  • 200
  • 286 a.a.
Protein Preferred Names Protein Names

translocon-associated protein subunit alpha

  • SSR alpha subunit

SSR1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
SSR1 P43307 CANX Homo sapiens P27824
Anti Bait CoIP
22314232
Intra
SSR1 P43307 SERPINA1 Homo sapiens P01009
Anti Bait CoIP
17380188
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SSR1 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P77493 Somatostatin R1/SSR1 Protein, Human (HEK293, Fc) P43307-1/NP_003135.2 (V19-T207) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type
Benign Pleural Mesothelioma

  • Mesothelioma Of Pleura

  • Benign Neoplasm Of Mesothelial Tissue Of Pleura

  • Pleural Malignant Mesothelioma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS13814 SSR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19959 Ssr1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26461 Ssr1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SSR1 VGNC VGNC:35319
Rattus norvegicus SSR1 RGD RGD:1310961
Mus musculus SSR1 MGD MGI:105082
Felis catus SSR1 VGNC VGNC:65708
Macaca mulatta SSR1 VGNC VGNC:77888
Canis familiaris SSR1 VGNC VGNC:46837
Others SSR1 NCBI