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  5. Syndecan-1/CD138 Protein, Human (HEK293, Fc)

Syndecan-1/CD138 Protein, Human (HEK293, Fc)

Cat. No.: HY-P77851
COA Handling Instructions

Syndecan-1/CD138 Protein, a cell surface proteoglycan, connects the cytoskeleton to the interstitial matrix with heparan sulfate and chondroitin sulfate. It regulates exosome biogenesis with SDCBP and PDCD6IP. Syndecan-1/CD138 Protein induces its own expression through an MSX1 pathway in dental cells and interacts with CDCP1 and TIAM1. It also interacts with MDK, participating in diverse cellular processes. Syndecan-1/CD138 Protein, Human (HEK293, Fc) is the recombinant human-derived Syndecan-1/CD138 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Syndecan-1/CD138 Protein, Human (HEK293, Fc) is 232 a.a., with molecular weight of 70-100 kDa.

For research use only. We do not sell to patients.

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  • Biological Activity

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Description

Syndecan-1/CD138 Protein, a cell surface proteoglycan, connects the cytoskeleton to the interstitial matrix with heparan sulfate and chondroitin sulfate. It regulates exosome biogenesis with SDCBP and PDCD6IP. Syndecan-1/CD138 Protein induces its own expression through an MSX1 pathway in dental cells and interacts with CDCP1 and TIAM1. It also interacts with MDK, participating in diverse cellular processes. Syndecan-1/CD138 Protein, Human (HEK293, Fc) is the recombinant human-derived Syndecan-1/CD138 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Syndecan-1/CD138 Protein, Human (HEK293, Fc) is 232 a.a., with molecular weight of 70-100 kDa.

Background

Syndecan-1/CD138 Protein is a cell surface proteoglycan characterized by the presence of heparan sulfate and chondroitin sulfate, which enables its role in connecting the cytoskeleton to the interstitial matrix. It collaborates with SDCBP and PDCD6IP to regulate exosome biogenesis. Furthermore, Syndecan-1/CD138 Protein has the ability to induce its own expression not only in dental mesenchymal cells but also in adjacent dental epithelial cells through an MSX1-mediated pathway. It interacts with CDCP1 and TIAM1, specifically through its C-terminus and the PDZ domain of TIAM1, respectively. Additionally, Syndecan-1/CD138 Protein interacts with MDK, facilitating its involvement in various cellular processes.

Biological Activity

Measured by its binding ability in a functional ELISA. When immobilized Human Syndecan-1,hFc Tag at 1μg/ml (100μl/Well), can bind Biotinylated Anti-Syndecan-1 Antibody, hFc Tag and the EC50 is 18 ng/mL.

Species

Human

Source

HEK293

Tag

C-hFc

Accession

P18827 (Q23-G254)

Gene ID
Molecular Construction
N-term
CD138 (Q23-G254)
Accession # P18827
hFc
C-term
Synonyms
Syndecan-1; SYND1; CD138; SDC1; SDC; SDC1
Molecular Weight

70-100 kDa

Purity

Greater than 95% as determined by Tris-Bis PAGE

Appearance

Lyophilized powder.

Formulation

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

Storage & Stability

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Documentation

Syndecan-1/CD138 Protein, Human (HEK293, Fc) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Syndecan-1/CD138 Protein, Human (HEK293, Fc)
Cat. No.:
HY-P77851
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