Syndecan-1/CD138 Protein, Human (HEK293, Fc)

Syndecan-1/CD138 Protein, a cell surface proteoglycan, connects the cytoskeleton to the interstitial matrix with heparan sulfate and chondroitin sulfate. It regulates exosome biogenesis with SDCBP and PDCD6IP. Syndecan-1/CD138 Protein induces its own expression through an MSX1 pathway in dental cells and interacts with CDCP1 and TIAM1. It also interacts with MDK, participating in diverse cellular processes. Syndecan-1/CD138 Protein, Human (HEK293, Fc) is the recombinant human-derived Syndecan-1/CD138 protein, expressed by HEK293 , with C-hFc labeled tag.

Syndecan-1/CD138 Protein is a cell surface proteoglycan characterized by the presence of heparan sulfate and chondroitin sulfate, which enables its role in connecting the cytoskeleton to the interstitial matrix. It collaborates with SDCBP and PDCD6IP to regulate exosome biogenesis. Furthermore, Syndecan-1/CD138 Protein has the ability to induce its own expression not only in dental mesenchymal cells but also in adjacent dental epithelial cells through an MSX1-mediated pathway. It interacts with CDCP1 and TIAM1, specifically through its C-terminus and the PDZ domain of TIAM1, respectively. Additionally, Syndecan-1/CD138 Protein interacts with MDK, facilitating its involvement in various cellular processes.

Measured by its binding ability in a functional ELISA. When immobilized Human Syndecan-1,hFc Tag at 1μg/ml (100μl/Well), can bind Biotinylated Anti-Syndecan-1 Antibody, hFc Tag and the EC₅₀ is 18 ng/mL.

Human

HEK293

C-hFc

P18827 (Q23-G254)

6382  [NCBI]

Extracellular Domain

QIVATNLPPEDQDGSGDDSDNFSGSGAGALQDITLSQQTPSTWKDTQLLTAIPTSPEPTGLEATAASTSTLPAGEGPKEGEAVVLPEVEPGLTAREQEATPRPRETTQLPTTHLASTTTATTAQEPATSHPHRDMQPGHHETSTPAGPSQADLHTPHTEDGGPSATERAAEDGASSQLPAAEGSGEQDFTFETSGENTAVVAVEPDRRNQSPVDQGATGASQGLLDRKEVLG

70-100 kDa

≥ 95%, as determined by Bis-Tris PAGE.

Lyophilized powder.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4, 8% trehalose.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.