SDC1 - syndecan 1 Gene
Also Known as SDC; CD138; SYND1; syndecan
Species: Homo sapiens
About SDC1
This gene has 6 transcripts (splice variants), 135 orthologues and 3 paralogues. Broad expression in esophagus (RPKM 110.6), skin (RPKM 101.9) and 14 other tissues.
Summary
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq, Jul 2008]
SDC1 Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_001006946.2 | NP_001006947.2 | syndecan-1 precursor |
| NM_002997.5 | NP_002988.4 | syndecan-1 precursor |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables identical protein binding |
IPI
IPI: Inferred from physical interaction
|
18093920 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
15292202 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in positive regulation of exosomal secretion |
IMP
IMP: Inferred from mutant phenotype
|
22660413 | GOA |
| involved in positive regulation of extracellular exosome assembly |
IMP
IMP: Inferred from mutant phenotype
|
22660413 | GOA |
| involved in striated muscle cell development |
IEP
IEP: Inferred from expression pattern
|
9566955 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in cell surface |
IDA
IDA: Inferred from direct assay
|
25063885 | GOA |
SDC1 Protein Structure
Syndecan: Syndecan domain (243 - 308)
- 0
- 100
- 200
- 310 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
syndecan-1 |
|
SDC1 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
SDC1 | P18827 | SDC2 | Homo sapiens | P34741 | 18093920 | |
|
Intra
|
SDC1 | P18827 | DHRS2 | Homo sapiens | Q13268 | 28514442 | |
|
Intra
|
SDC1 | P18827 | EEPD1 | Homo sapiens | Q7L9B9 | 33961781 | |
|
Intra
|
SDC1 | P18827 | CSNK1G2 | Homo sapiens | P78368 | 33961781 | |
|
Intra
|
SDC1 | P18827 | EEPD1 | Homo sapiens | Q7L9B9 | 28514442 | |
|
Intra
|
SDC1 | P18827 | CSNK1G2 | Homo sapiens | P78368 | 28514442 | |
|
Intra
|
SDC1 | P18827 | SDC1 | Homo sapiens | P18827 | 18093920 | |
|
Intra
|
SDC1 | P18827 | DHRS2 | Homo sapiens | Q13268 | 33961781 | |
|
Intra
|
SDC1 | P18827 | SDC1 | Homo sapiens | P18827 | 18093920 | |
|
Intra
|
SDC1 | P18827 | EPHA2 | Homo sapiens | P29317 | 28514442 |
Recombinant SDC1 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P72479 | Syndecan-1/CD138 Protein, Human (HEK293, His) | P18827 (Q18-E251) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P77851 | Syndecan-1/CD138 Protein, Human (HEK293, Fc) | P18827 (Q23-G254) | ≥ 95%, as determined by Bis-Tris PAGE. |
| HY-P77852 | Syndecan-1/CD138 Protein, Human (Biotinylated, HEK293, His-Avi) | P18827 (Q23-G254) | ≥ 95%, as determined by Bis-Tris PAGE. |
| HY-P78809 | Syndecan-1/CD138 Protein, Human (Biotinylated, HEK293, Fc-Avi) | P18827 (Q23-G254) | ≥ 90%, as determined by reducing SDS-PAGE. |
SDC1 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P81745 | Syndecan 1 Antibody (YA1490) | WB, IHC-P, ICC/IF, FC | Human, Mouse, Rat |
| HY-P82781 | Syndecan 1 Antibody (YA2526) | WB, IHC-P, ICC/IF | Human, Mouse, Rat |
| HY-P84146 | Syndecan 1 Antibody (YA3843) | WB, IHC-P, ICC/IF, FC, ELISA | Human, Mouse |
| HY-P84146A | Syndecan 1 Antibody (YA3843)(PBS only) | WB, IHC-P, ICC/IF, FC, ELISA | Human, Mouse |
| HY-P84963 | Syndecan 1 Antibody (YA7079) |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Endometritis |
|
|
| Intestinal Disease |
|
|
| Monoclonal Gammopathy Of Uncertain Significance |
|
|
| Macroglobulinemia |
|
|
| Monoclonal Paraproteinemia |
|
|
| Smoldering Myeloma |
|
|
| Extramedullary Plasmacytoma |
|
|
| Solitary Osseous Plasmacytoma |
|
|
| Multicentric Castleman Disease |
|
|
| Blood Protein Disease |
|
|
| Lymphoplasmacyte-Rich Meningioma |
|
|
| Diverticulitis |
|
|
| Gamma Heavy Chain Disease |
|
|
| Intellectual Developmental Disorder, Autosomal Dominant 36 |
|
|
| Non-Secretory Myeloma |
|
|
| Igg4-Related Disease |
|
|
| Lymphoplasmacytic Lymphoma |
|
|
| Plasmablastic Lymphoma |
|
|
| Mature B-Cell Neoplasm |
|
|
| Kaposi Sarcoma |
|
|
| Refractory Plasma Cell Neoplasm |
|
|
| Granulomatous Endometritis |
|
|
| Infected Hydrocele |
|
|
| Plasma Cell Leukemia |
|
|
| Post-Cardiac Arrest Syndrome |
|
|
| Immunoglobulin Light Chain Amyloidosis |
|
|
| Endometrial Disease |
|
|
| Bone Marrow Cancer |
|
|
| Keratoacanthoma |
|
|
| Pleural Empyema |
|
|
| Leukocyte Disease |
|
|
| Plasma Protein Metabolism Disease |
|
|
| Epidural Spinal Canal Neoplasm |
|
|
| Mechanical Ectropion |
|
|
| Hepatocellular Carcinoma |
|
|
| Waldenstroem'S Macroglobulinemia |
|
|
| Castleman Disease |
|
|
| Autoimmune Pancreatitis |
|
|
| Marginal Zone B-Cell Lymphoma |
|
|
| Plasma Cell Neoplasm |
|
|
| Maxillonasal Dysplasia, Binder Type |
|
|
| Colorectal Cancer |
|
|
| Thymus Large Cell Carcinoma |
|
|
| Ureteral Lymphoma |
|
|
| Submucous Uterine Fibroid |
|
|
| Paranasal Sinus Lymphoma |
|
|
| Lymphoma, Mucosa-Associated Lymphoid Type |
|
|
| Myopathy, Lactic Acidosis, And Sideroblastic Anemia 3 |
|
|
| Mantle Cell Lymphoma |
|
|
| Malignant Histiocytic Disease |
|
|
| Breast Cancer |
|
|
| Myeloma, Multiple |
|
|
| Lymphoma, Non-Hodgkin, Familial |
|
|
| Leukemia, Chronic Lymphocytic |
|
|
| Leukemia, Acute Myeloid |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Macaca mulatta | SDC1 | VGNC | VGNC:76997 |
| Bos taurus | SDC1 | VGNC | VGNC:34378 |
| Canis familiaris | SDC1 | VGNC | VGNC:45942 |
| Mus musculus | SDC1 | MGD | MGI:1349162 |
| Rattus norvegicus | SDC1 | RGD | RGD:3648 |
| Felis catus | SDC1 | VGNC | VGNC:64943 |
| Others | SDC1 | NCBI |