Syntaxin-8 Protein, Human
Syntaxin-8 is a vesicular transport protein that promotes retrograde transport within the early secretory pathway. It is essential for homotypic fusion of late endosomes, forming a SNARE complex with STX7, VTI1B, and VAMP8. Syntaxin-8 Protein, Human is the recombinant human-derived Syntaxin-8 protein, expressed by E. coli , with tag free.
- Species: Human
- Source: E. coli
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Biological Activity
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Product Properties
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Biological Activity
Syntaxin-8 is a vesicular transport protein that promotes retrograde transport within the early secretory pathway. It is essential for homotypic fusion of late endosomes, forming a SNARE complex with STX7, VTI1B, and VAMP8. Syntaxin-8 Protein, Human is the recombinant human-derived Syntaxin-8 protein, expressed by E. coli , with tag free.
Syntaxin-8, a vesicle trafficking protein, operates within the early secretory pathway, potentially facilitating retrograde transport from cis-Golgi membranes to the endoplasmic reticulum (ER). It plays a crucial role in homotypic fusion of late endosomes by forming a SNARE complex with STX7, VTI1B, and VAMP8. As a component of the SNARE core complex containing STX7, VAMP8, and VTI1B, Syntaxin-8 engages in intricate molecular interactions. It interacts with VAMP8, contributing to the coordination of vesicle fusion events. Additionally, Syntaxin-8 interacts with HECTD3 and TPC1, further highlighting its involvement in diverse cellular processes and emphasizing its significance in vesicle trafficking and membrane fusion events.
Technical Parameters
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Species Human
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Source E. coli
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Tag Tag Free
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Accession
Q9UNK0 (M1-G215)
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Molecular Construction
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N-term
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Syntaxin-8 (M1-G215)
Accession # Q9UNK0 -
C-term
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Protein Length
Partial
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Synonyms
Syntaxin-8; STX8
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AA Sequence
MAPDPWFSTYDSTCQIAQEIAEKIQQRNQYERKGEKAPKLTVTIRALLQNLKEKIALLKDLLLRAVSTHQITQLEGDRRQNLLDDLVTRERLLLASFKNEGAEPDLIRSSLMSEEAKRGAPNPWLFEEPEETRGLGFDEIRQQQQKIIQEQDAGLDALSSIISRQKQMGQEIGNELDEQNEIIDDLANLVENTDEKLRNETRRVNMVDRKSASCG
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Predicted Molecular Mass
24.6 kDa
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Molecular Weight
Approximately 28 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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