STX8 - syntaxin 8 Gene

Also Known as CARB

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9482

About STX8

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:9,250,471-9,575,820 (from NCBI)

This gene has 12 transcripts (splice variants), 189 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 14.6), fat (RPKM 9.7) and 25 other tissues.

Summary

The gene is a member of the syntaxin family. The encoded protein is involved in protein trafficking from early to late endosomes via vesicle fusion and exocytosis. A related pseudogene has been identified on chromosome 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

STX8 Products (1)

mRNA Protein Name
NM_004853.3 NP_004844.1 syntaxin-8

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chloride channel inhibitor activity IDA
IDA: Inferred from direct assay
18570918 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables syntaxin binding IPI
IPI: Inferred from physical interaction
10564279 GOA
Biological Process GO Annotation Evidence References Source
involved in early endosome to late endosome transport IDA
IDA: Inferred from direct assay
10564279 GOA
involved in regulation of protein localization to plasma membrane IDA
IDA: Inferred from direct assay
18570918 GOA
Cellular Component GO Annotation Evidence References Source
located in early endosome IDA
IDA: Inferred from direct assay
10564279 GOA
located in endosome IDA
IDA: Inferred from direct assay
10564279 GOA
located in late endosome IDA
IDA: Inferred from direct assay
10564279 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
18570918 GOA
located in recycling endosome IDA
IDA: Inferred from direct assay
18570918 GOA
located in trans-Golgi network IDA
IDA: Inferred from direct assay
10564279 GOA
located in vesicle IDA
IDA: Inferred from direct assay
18570918 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STX8 Protein Structure

SNARE

SNARE: SNARE domain (150 - 211)

  • 0
  • 100
  • 200
  • 236 a.a.
Protein Preferred Names Protein Names

syntaxin-8

  • CIP-1-associated regulator of cyclin B

STX8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
STX8 Q9UNK0 MCL1 Homo sapiens Q07820
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 MCL1 Homo sapiens Q07820
Y2H Array
32296183
Intra
STX8 Q9UNK0 RETREG3 Homo sapiens Q86VR2
Y2H Array
32296183
Intra
STX8 Q9UNK0 RETREG3 Homo sapiens Q86VR2
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 JAGN1 Homo sapiens Q8N5M9
Y2H Array
32296183
Intra
STX8 Q9UNK0 JAGN1 Homo sapiens Q8N5M9
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 MCEE Homo sapiens Q96PE7
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 MCEE Homo sapiens Q96PE7
Y2H Array
32296183
Intra
STX8 Q9UNK0 SGPL1 Homo sapiens O95470
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 SGPL1 Homo sapiens O95470
Y2H Array
32296183
Intra
STX8 Q9UNK0 TMEM237 Homo sapiens Q96Q45-2
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 TMEM237 Homo sapiens Q96Q45-2
Y2H Array
32296183
Intra
STX8 Q9UNK0 JSRP1 Homo sapiens Q96MG2
Y2H Array
32296183
Intra
STX8 Q9UNK0 JSRP1 Homo sapiens Q96MG2
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 JSRP1 Homo sapiens Q96MG2
MAPPIT
32296183
Intra
STX8 Q9UNK0 MGST2 Homo sapiens Q99735
Y2H Array
32296183
Intra
STX8 Q9UNK0 MGST2 Homo sapiens Q99735
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 TMED8 Homo sapiens Q6PL24
Y2H Array
32296183
Intra
STX8 Q9UNK0 TMED8 Homo sapiens Q6PL24
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
Intra
STX8 Q9UNK0 TMEM179B Homo sapiens Q7Z7N9
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 TMEM179B Homo sapiens Q7Z7N9
Y2H Array
32296183
Intra
STX8 Q9UNK0 TMPPE Homo sapiens Q6ZT21
Y2H Array
32296183
Intra
STX8 Q9UNK0 TMPPE Homo sapiens Q6ZT21
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 GPR151 Homo sapiens Q8TDV0
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 GPR151 Homo sapiens Q8TDV0
Y2H Array
32296183
Intra
STX8 Q9UNK0 MFF Homo sapiens Q9GZY8-5
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 MFF Homo sapiens Q9GZY8-5
Y2H Array
32296183
Intra
STX8 Q9UNK0 STX2 Homo sapiens P32856-2
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 STX2 Homo sapiens P32856-2
Y2H Array
32296183
Intra
STX8 Q9UNK0 FNDC9 Homo sapiens Q8TBE3
Y2H Array
32296183
Intra
STX8 Q9UNK0 FNDC9 Homo sapiens Q8TBE3
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 TMPRSS2 Homo sapiens O15393-2
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 TMPRSS2 Homo sapiens O15393-2
Y2H Array
32296183
Intra
STX8 Q9UNK0 MS4A3 Homo sapiens Q96HJ5
Y2H Array
32296183
Intra
STX8 Q9UNK0 MS4A3 Homo sapiens Q96HJ5
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 ASGR2 Homo sapiens P07307-3
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 ASGR2 Homo sapiens P07307-3
Y2H Array
32296183
Intra
STX8 Q9UNK0 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra
STX8 Q9UNK0 NCR3LG1 Homo sapiens Q68D85
Y2H Array
32296183
Intra
STX8 Q9UNK0 NCR3LG1 Homo sapiens Q68D85
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 SCN3B Homo sapiens Q9NY72
Y2H Array
32296183
Intra
STX8 Q9UNK0 SCN3B Homo sapiens Q9NY72
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 SSMEM1 Homo sapiens Q8WWF3
Y2H Array
32296183
Intra
STX8 Q9UNK0 SSMEM1 Homo sapiens Q8WWF3
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 GJA8 Homo sapiens P48165
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 GJA8 Homo sapiens P48165
Y2H Array
32296183
Intra
STX8 Q9UNK0 GJB1 Homo sapiens P08034
Y2H Array
32296183
Intra
STX8 Q9UNK0 GJB1 Homo sapiens P08034
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 SLC18A1 Homo sapiens P54219-3
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 SLC18A1 Homo sapiens P54219-3
Y2H Array
32296183
Intra
STX8 Q9UNK0 KCNMB1 Homo sapiens Q16558-2
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 KCNMB1 Homo sapiens Q16558-2
Y2H Array
32296183
Intra
STX8 Q9UNK0 CD300E Homo sapiens Q496F6
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 CD300E Homo sapiens Q496F6
Y2H Array
32296183
Intra
STX8 Q9UNK0 CPLX4 Homo sapiens Q7Z7G2
Y2H Array
32296183
Intra
STX8 Q9UNK0 CPLX4 Homo sapiens Q7Z7G2
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 GPR42 Homo sapiens O15529
Y2H Array
32296183
Intra
STX8 Q9UNK0 GPR42 Homo sapiens O15529
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 SLC10A6 Homo sapiens Q3KNW5
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 SLC10A6 Homo sapiens Q3KNW5
Y2H Array
32296183
Intra
STX8 Q9UNK0 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra
STX8 Q9UNK0 CLDN9 Homo sapiens O95484
Y2H Array
32296183
Intra
STX8 Q9UNK0 CLDN9 Homo sapiens O95484
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 RNASEK Homo sapiens Q6P5S7
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 RNASEK Homo sapiens Q6P5S7
Y2H Array
32296183
Intra
STX8 Q9UNK0 FAM174A Homo sapiens Q8TBP5
Y2H Array
32296183
Intra
STX8 Q9UNK0 FAM174A Homo sapiens Q8TBP5
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 AMIGO1 Homo sapiens Q86WK6
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 AMIGO1 Homo sapiens Q86WK6
Y2H Array
32296183
Intra
STX8 Q9UNK0 DHRS9 Homo sapiens Q9BPW9-4
Y2H Array
32296183
Intra
STX8 Q9UNK0 DHRS9 Homo sapiens Q9BPW9-4
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 STMN4 Homo sapiens Q9H169-2
Y2H Array
32296183
Intra
STX8 Q9UNK0 STMN4 Homo sapiens Q9H169-2
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 TSPAN12 Homo sapiens O95859
Y2H Array
32296183
Intra
STX8 Q9UNK0 TSPAN12 Homo sapiens O95859
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 TMEM86B Homo sapiens Q8N661
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 TMEM86B Homo sapiens Q8N661
Y2H Array
32296183
Intra
STX8 Q9UNK0 CERS4 Homo sapiens Q9HA82
Y2H Array
32296183
Intra
STX8 Q9UNK0 CERS4 Homo sapiens Q9HA82
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 NDUFAF2 Homo sapiens Q8N183
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 NDUFAF2 Homo sapiens Q8N183
Y2H Array
32296183
Intra
STX8 Q9UNK0 FFAR2 Homo sapiens O15552
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 FFAR2 Homo sapiens O15552
Y2H Array
32296183
Intra
STX8 Q9UNK0 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra
STX8 Q9UNK0 GORAB Homo sapiens Q5T7V8
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 GORAB Homo sapiens Q5T7V8
Y2H Array
32296183
Intra
STX8 Q9UNK0 FKBP7 Homo sapiens Q9Y680
Y2H Array
32296183
Intra
STX8 Q9UNK0 FKBP7 Homo sapiens Q9Y680
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 FKBP7 Homo sapiens Q9Y680
Validated Y2H
32296183
Intra
STX8 Q9UNK0 SAR1A Homo sapiens Q9NR31
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 SAR1A Homo sapiens Q9NR31
Y2H Array
32296183
Intra
STX8 Q9UNK0 PEX12 Homo sapiens O00623
Y2H Array
32296183
Intra
STX8 Q9UNK0 PEX12 Homo sapiens O00623
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 MMGT1 Homo sapiens Q8N4V1
Y2H Array
32296183
Intra
STX8 Q9UNK0 MMGT1 Homo sapiens Q8N4V1
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 TMEM205 Homo sapiens Q6UW68
Y2H Array
32296183
Intra
STX8 Q9UNK0 TMEM205 Homo sapiens Q6UW68
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
STX8 Q9UNK0 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 BIK Homo sapiens Q13323
Y2H Array
32296183
Intra
STX8 Q9UNK0 BIK Homo sapiens Q13323
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 STX1A Homo sapiens Q16623
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 STX1A Homo sapiens Q16623
Y2H Array
32296183
Intra
STX8 Q9UNK0 STX5 Homo sapiens Q13190
Anti Tag CoIP
33961781
Intra
STX8 Q9UNK0 STAR Homo sapiens P49675
Y2H Array
32296183
Intra
STX8 Q9UNK0 STAR Homo sapiens P49675
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 VTI1B Homo sapiens Q9UEU0
Anti Tag CoIP
35271311
Intra
STX8 Q9UNK0 VTI1B Homo sapiens Q9UEU0
Y2H
21516116
Intra
STX8 Q9UNK0 VTI1B Homo sapiens Q9UEU0
Y2H Pooling
16189514
Intra
STX8 Q9UNK0 VTI1B Homo sapiens Q9UEU0
Anti Tag CoIP
33961781
Intra
STX8 Q9UNK0 VTI1B Homo sapiens Q9UEU0
Y2H Array
31515488
Intra
STX8 Q9UNK0 MGST3 Homo sapiens O14880
Y2H Array
32296183
Intra
STX8 Q9UNK0 MGST3 Homo sapiens O14880
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 NDUFAF1 Homo sapiens Q9Y375
Validated Y2H
32296183
Intra
STX8 Q9UNK0 NDUFAF1 Homo sapiens Q9Y375
Y2H Array
32296183
Intra
STX8 Q9UNK0 NDUFAF1 Homo sapiens Q9Y375
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 STX4 Homo sapiens Q12846
Y2H Array
32296183
Intra
STX8 Q9UNK0 STX4 Homo sapiens Q12846
Anti Tag CoIP
33961781
Intra
STX8 Q9UNK0 STX4 Homo sapiens Q12846
Y2H Prey Pooling
25416956
Intra
STX8 Q9UNK0 STX4 Homo sapiens Q12846
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 BCL2L13 Homo sapiens Q9BXK5
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 BCL2L13 Homo sapiens Q9BXK5
Y2H Array
32296183
Intra
STX8 Q9UNK0 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra
STX8 Q9UNK0 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra
STX8 Q9UNK0 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
STX8 Q9UNK0 MTERF3 Homo sapiens Q96E29
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 MTERF3 Homo sapiens Q96E29
Y2H Array
32296183
Intra
STX8 Q9UNK0 BSND Homo sapiens Q8WZ55
Y2H Prey Pooling
32296183
Intra
STX8 Q9UNK0 BSND Homo sapiens Q8WZ55
Y2H Array
32296183
Intra
STX8 Q9UNK0 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Intra
STX8 Q9UNK0 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant STX8 Proteins

Cat. No. Product Name Accession Purity
HY-P71348 Syntaxin-8 Protein, Human Q9UNK0 (M1-G215) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Hemophagocytic Lymphohistiocytosis, Familial, 4

  • Familial Hemophagocytic Lymphohistiocytosis 4

  • FHL4

  • Hplh4

  • Hlh4

  • Lymphohistiocytosis, Hemophagocytic, Familial, Type 4
Oculoglandular Tularemia
Visual Epilepsy

  • Seizures

  • Epilepsy, Visual

  • Visual Seizure

  • Acute Symptomatic Seizure

  • Provoked Seizure

  • Nonepileptic Seizure Disorder

  • Uncontrolled Seizures

  • Seizure Nos

  • Fits Nos

  • Onset Seizure Nos

  • Seizure Disturbance
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13988 STX8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20342 Stx8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26850 Stx8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus STX8 MGD MGI:1890156
Bos taurus STX8 VGNC VGNC:35444
Felis catus STX8 VGNC VGNC:65817
Canis familiaris STX8 VGNC VGNC:53452
Rattus norvegicus STX8 RGD RGD:61917
Macaca mulatta STX8 VGNC VGNC:78048
Others STX8 NCBI