STX8 - syntaxin 8 Gene

Homo sapiens

Also known as CARB

Gene ID: 9482 | Gene type: protein coding

About STX8

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:9,250,471-9,575,820 (from NCBI)

This gene has 12 transcripts (splice variants), 189 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 14.6), fat (RPKM 9.7) and 25 other tissues.

Summary

The gene is a member of the syntaxin family. The encoded protein is involved in protein trafficking from early to late endosomes via vesicle fusion and exocytosis. A related pseudogene has been identified on chromosome 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

STX8 Products(1)

mRNA	Protein	Name
NM_004853.3	NP_004844.1	syntaxin-8

STX8 Protein Structure

SNARE

0
100
200
236 a.a.

Protein Preferred Names

Protein Names

syntaxin-8

CIP-1-associated regulator of cyclin B

Recombinant STX8 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71348	Syntaxin-8 Protein, Human	Q9UNK0 (M1-G215)	≥95%

Related Diseases

Diseases

Alias

Hemophagocytic Lymphohistiocytosis, Familial, 4

Familial Hemophagocytic Lymphohistiocytosis 4	FHL4
Hplh4	Hlh4
Lymphohistiocytosis, Hemophagocytic, Familial, Type 4

Oculoglandular Tularemia

Visual Epilepsy

Seizures	Epilepsy, Visual
Visual Seizure	Acute Symptomatic Seizure
Provoked Seizure	Nonepileptic Seizure Disorder
Uncontrolled Seizures	Seizure Nos
Fits Nos	Onset Seizure Nos
Seizure Disturbance

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13988	STX8 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	STX8	MGD	MGI:1890156
Bos taurus	STX8	VGNC	VGNC:35444
Felis catus	STX8	VGNC	VGNC:65817
Canis familiaris	STX8	VGNC	VGNC:53452
Rattus norvegicus	STX8	RGD	RGD:61917
Macaca mulatta	STX8	VGNC	VGNC:78048
Others	STX8	NCBI