TALDO1 Protein, Human (HEK293, His)

The TALDO1 protein plays a key role in cellular metabolism by catalyzing the rate-limiting step in the non-oxidative phase of the pentose phosphate pathway. Multiple studies have shown that it promotes the reversible conversion of sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate into erythrose 4-phosphate and β-D-fructose 6-phosphate. TALDO1 Protein, Human (HEK293, His) is the recombinant human-derived TALDO1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TALDO1 Protein, Human (HEK293, His) is 337 a.a., with molecular weight of ~38.0 kDa.

The TALDO1 protein is a key enzyme in the pentose phosphate pathway, catalyzing the rate-limiting step of the non-oxidative phase. This enzyme facilitates the reversible conversion of sedoheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate. By regulating the flow of metabolites through the pentose phosphate pathway, TALDO1 plays a crucial role in generating ribose-5-phosphate and NADPH, essential for nucleotide biosynthesis and cellular redox balance, respectively. Moreover, TALDO1 exhibits additional regulatory functions by altering its subcellular localization between the nucleus and the cytoplasm, suggesting its involvement in the coordination of various metabolic pathways.

Human

HEK293

C-6*His

P37837 (M1-K337)

6888  [NCBI]

MSSSPVKRQRMESALDQLKQFTTVVADTGDFHAIDEYKPQDATTNPSLILAAAQMPAYQELVEEAIAYGRKLGGSQEDQIKNAIDKLFVLFGAEILKKIPGRVSTEVDARLSFDKDAMVARARRLIELYKEAGISKDRILIKLSSTWEGIQAGKELEEQHGIHCNMTLLFSFAQAVACAEAGVTLISPFVGRILDWHVANTDKKSYEPLEDPGVKSVTKIYNYYKKFSYKTIVMGASFRNTGEIKALAGCDFLTISPKLLGELLQDNAKLVPVLSAKAAQASDLEKIHLDEKSFRWLHNEDQMAVEKLSDGIRKFAADAVKLERMLTERMFNAENGK

Approximately 38.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.