TALDO1 - transaldolase 1 Gene

Also Known as TAL; TALH; TAL-H; TALDOR

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6888

About TALDO1

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:747,464-765,012 (from NCBI)

This gene has 9 transcripts (splice variants), 206 orthologues and is associated with 3 phenotypes. Ubiquitous expression in bone marrow (RPKM 165.6), esophagus (RPKM 127.9) and 25 other tissues.

Summary

Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals. The functional gene of transaldolase 1 is located on chromosome 11 and a pseudogene is identified on chromosome 1 but there are conflicting map locations. The second and third exon of this gene were developed by insertion of a retrotransposable element. This gene is thought to be involved in multiple sclerosis. [provided by RefSeq, Jul 2008]

TALDO1 Products (1)

mRNA Protein Name
NM_006755.2 NP_006746.1 transaldolase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21044950 GOA
enables transaldolase activity IDA
IDA: Inferred from direct assay
18687684 GOA
enables transaldolase activity IMP
IMP: Inferred from mutant phenotype
18498245 GOA
Biological Process GO Annotation Evidence References Source
involved in pentose-phosphate shunt, non-oxidative branch IMP
IMP: Inferred from mutant phenotype
18498245 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
18498245 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TALDO1 Protein Structure

TAL_FSA

TAL_FSA: Transaldolase/Fructose-6-phosphate aldolase (24 - 325)

  • 0
  • 100
  • 200
  • 300
  • 337 a.a.
Protein Preferred Names Protein Names

transaldolase

  • dihydroxyacetone transferase

TALDO1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TALDO1 P37837 HTT Homo sapiens P42858
Y2H Pooling
32814053
Intra
TALDO1 P37837 HTT Homo sapiens P42858
Validated Y2H
32814053
Intra
TALDO1 P37837 HTT Homo sapiens P42858
Y2H Array
32814053
Intra
TALDO1 P37837 TERF2IP Homo sapiens Q9NYB0
Pull Down
21044950
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TALDO1 Proteins

Cat. No. Product Name Accession Purity
HY-P71351 TALDO1 Protein, Human (HEK293, His) P37837 (M1-K337) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Transaldolase Deficiency

  • Taldo Deficiency

  • TALDOD

  • Eyaid Syndrome

  • Deficiency Of Transaldolase
Ribose 5-Phosphate Isomerase Deficiency

  • RPIAD

  • Deficiency Of Ribose-5-Phosphate Isomerase

  • Ribose-5-P Isomerase Deficiency

  • Ribose-5-Phosphate Isomerase Deficiency
Multiple Sclerosis

  • MS

  • Multiple Sclerosis, Susceptibility To

  • Disseminated Sclerosis

  • Multiple Sclerosis, Disease Progression, Modifier Of

  • Insular Sclerosis

  • Multiple Sclerosis Modifier Of Disease Progression

  • Multiple Sclerosis, Susceptibility To 1

  • Multiple Sclerosis, Susceptibility To, 1

  • Multiple Sclerosis 1

  • Generalized Multiple Sclerosis

  • Multiple Sclerosis Variant

  • Multiple Sclerosis Susceptibility To

  • Cerebrospinal Sclerosis

  • Generalised Multiple Sclerosis

  • Ms - [Multiple Sclerosis]

  • Disseminated Cerebrospinal Sclerosis

  • Disseminated Multiple Sclerosis

  • Disseminated Nervous System Myelosclerosis

  • Multiple Cerebrospinal Sclerosis

  • Multiple Combined Sclerosis

  • Multiple Sclerosis Generalised

  • Disseminated Brain Sclerosis

  • Disseminated Spinal Sclerosis

  • Insular Brain Sclerosis

  • Miliary Brain Sclerosis

  • Multiple Combined Sclerosis Of Spinal Cord

  • Multiple Ascending Sclerosis

  • Multiple Brain Sclerosis

  • Multiple Sclerosis Of Brain Stem

  • Multiple Sclerosis Of The Brain Stem

  • Multiple Sclerosis Of Cord

  • Sclérose En Plaques

  • Plaque Sclerosis

  • Multiple Sclerosis Of The Spinal Cord
Hypomagnesemia 5, Renal, With Or Without Ocular Involvement

  • Fhhnc With Severe Ocular Involvement

  • Renal Hypomagnesemia 5 With Ocular Involvement

  • Meier Blumberg Imahorn Syndrome

  • HOMG5

  • Hypomagnesemia, Renal, With Ocular Involvement

  • Hypomagnesemia 5, Renal, With Ocular Involvement

  • Familial Hypomagnesemia With Hypercalciuria, Nephrocalcinosis And Severe Ocular Involvement

  • Hypercalciuria-Bilateral Macular Coloboma Syndrome

  • Meier-Blumberg-Imahorn Syndrome

  • Hypomagnesemia, Familial, With Hypercalciuria, Nephrocalcinosis, And Severe Ocular Involvement

  • Macular Coloboma, Bilateral, With Hypercalciuria

  • Bilateral Macular Coloboma With Hypercalciuria

  • Idiopathic Hypercalciuria With Bilateral Macular Colobomata

  • Primary Hypomagnesemia With Hypercalciuria And Nephrocalcinosis With Severe Ocular Involvement

  • Hypomagnesemia 5

  • Hypomagnesemia 5 Renal With Ocular Involvement

  • Hypomagnesemia Renal With Ocular Involvement

  • Macular Coloboma Bilateral With Hypercalciuria

  • Hypomagnesemia, Type 5, Renal, With Ocular Involvement
Liver Cirrhosis

  • Cirrhosis

  • Cirrhosis Of Liver

  • CIRRH

  • Cryptogenic Cirrhosis

  • Cirrhosis, Cryptogenic

  • Cirrhosis Nos
Cutis Laxa

  • Generalized Elastolysis

  • Loose Skin

  • Dermatolysis

  • Dermatomegaly

  • Cutis Laxa Syndrome
Senile Cataract
Esophagus Sarcoma

  • Esophageal Sarcoma
Pancytopenia
Heart Disease

  • Heart Failure

  • Congenital Heart Disease

  • Heart Diseases

  • Congenital Heart Defects

  • Congenital Heart Defect

  • Heart Malformation

  • Congenital Anomaly Of Heart

  • Heart Defect

  • Heart-Congenital Defect

  • Congenital Heart Disorder

  • Heart Defects Congenital

  • Heart Defects, Congenital

  • Heart Defects

  • Heart Disease, Congenital

  • Disease, Heart, Congenital

  • Congestive Heart Failure
Amyotrophic Lateral Sclerosis 1

  • Amyotrophic Lateral Sclerosis

  • ALS

  • Lou Gehrig Disease

  • Amyotrophic Lateral Sclerosis Type 1

  • Charcot Disease

  • ALS1

  • Amyotrophic Lateral Sclerosis, Susceptibility To

  • Fals

  • Lou Gehrig'S Disease

  • Mnd

  • Motor Neuron Disease

  • Familial Amyotrophic Lateral Sclerosis

  • Amyotrophic Lateral Sclerosis 1, Familial

  • Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

  • Motor Neuron Disease, Bulbar

  • Motor Neurone Disease

  • Amyotrophic Lateral Sclerosis With Dementia

  • Dementia With Amyotrophic Lateral Sclerosis

  • Motor Neuron Disease, Amyotrophic Lateral Sclerosis

  • Sclerosis, Lateral, Amyotrophic

  • Sclerosis, Lateral, Amyotrophic, Type 1

  • Amyotrophic Sclerosis

  • Als - [Amyotrophic Lateral Sclerosis]

  • Wasting Palsy

  • Amyotrophic Paralysis

  • Amyotrophy Lateral Sclerosis

  • Wasting Paralysis

  • Spinal Progressive Amyotrophy

  • Progressive Atrophic Paralysis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-159130 AO-022 / Unkown
HY-RS14191 TALDO1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18878 Taldo1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25369 Taldo1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TALDO1 RGD RGD:620674
Macaca mulatta TALDO1 VGNC VGNC:78096
Mus musculus TALDO1 MGD MGI:1274789
Bos taurus TALDO1 VGNC VGNC:35590
Felis catus TALDO1 VGNC VGNC:65947
Others TALDO1 NCBI