TIM-1/KIM-1/HAVCR Protein, Rat (HEK293, His-Fc)

TIM-1/KIM-1/HAVCR protein is a phosphatidylserine receptor that plays a crucial regulatory role in regulatory B cells, affecting their generation, expansion and inhibitory functions. It acts as a ligand for P-selectin/SELPLG and controls activated T cell trafficking during inflammatory responses. TIM-1/KIM-1/HAVCR Protein, Rat (HEK293, His-Fc) is the recombinant rat-derived TIM-1/KIM-1/HAVCR protein, expressed by HEK293 , with N-hFc, C-His labeled tag. The total length of TIM-1/KIM-1/HAVCR Protein, Rat (HEK293, His-Fc) is 221 a.a., with molecular weight of 90-100 kDa.

TIM-1/KIM-1/HAVCR Protein serves as a phosphatidylserine receptor with a crucial functional role in the homeostasis of regulatory B-cells, influencing their generation, expansion, and suppressor functions. Additionally, as a ligand for P-selectin/SELPLG, it assumes a specialized role in the trafficking of activated T-cells during inflammatory responses, particularly controlling T-cell accumulation in the inflamed central nervous system and influencing the induction of autoimmune disease. TIM-1/KIM-1/HAVCR also regulates the expression of various anti-inflammatory cytokines and co-inhibitory ligands, including IL10, acting as a modulator of T-cell proliferation. Furthermore, it may play a role in kidney injury and repair. Interactions with STAM and SELPLG contribute to the multifaceted regulatory functions of TIM-1/KIM-1/HAVCR Protein.

Rat

HEK293

N-hFc;C-His

O54947 (S18-V238)

286934  [NCBI]

90-100 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.