TMED1 Protein, Human (HEK293, Fc)

The TMED1 protein may facilitate vesicular protein trafficking in the early secretory pathway, acting as a cargo receptor on the luminal side to incorporate secretory cargo into transport vesicles. It is involved in the formation of the vesicle shell on the cytoplasmic side and positively affects IL-33-mediated IL-8 and IL-6 production by interacting with IL1RL1. TMED1 Protein, Human (HEK293, Fc) is the recombinant human-derived TMED1 protein, expressed by HEK293 , with C-hFc labeled tag.

The TMED1 protein potentially plays a role in vesicular protein trafficking, particularly in the early secretory pathway. It may act as a cargo receptor on the lumenal side to facilitate the incorporation of secretory cargo molecules into transport vesicles, and it is also implicated in vesicle coat formation on the cytoplasmic side. Additionally, TMED1 has been shown to have a positive influence on IL-33-mediated IL-8 and IL-6 production by interacting with the interleukin-33 receptor IL1RL1. Furthermore, it is involved in the modulation of innate immune signaling through the cGAS-STING pathway via its interaction with RNF26. TMED1 forms homodimers in the endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment, and cis-Golgi network. It interacts with IL1RL1 and RNF26, with the latter interaction being particularly important for modulating innate immune signaling through the cGAS-STING pathway.

Human

HEK293

C-hFc

Q13445 (A24-N194)

11018  [NCBI]

Extracellular Domain

AGPPPIQDGEFTFLLPAGRKQCFYQSAPANASLETEYQVIGGAGLDVDFTLESPQGVLLVSESRKADGVHTVEPTEAGDYKLCFDNSFSTISEKLVFFELIFDSLQDDEEVEGWAEAVEPEEMLDVKMEDIKESIETMRTRLERSIQMLTLLRAFEARDRNLQEGNLERVN

Approximately 55-65 kDa, based on SDS-PAGE under reducing conditions.

≥ 90%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.