TMED1 - transmembrane p24 trafficking protein 1 Gene

Also Known as Tp24; p24g1; Il1rl1l; IL1RL1LG

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11018

About TMED1

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:10,832,067-10,836,212 (from NCBI)

This gene has 7 transcripts (splice variants), 256 orthologues and 8 paralogues. Ubiquitous expression in placenta (RPKM 10.9), kidney (RPKM 10.9) and 25 other tissues.

Summary

This gene belongs to the TMED (transmembrane emp24 domain-containing) protein family, which is involved in the vesicular trafficking of proteins. The protein encoded by this gene was identified by its interaction with interleukin 1 receptor-like 1 (IL1RL1) and may play a role in innate immunity. This protein lacks any similarity to Other interleukin 1 ligands. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

TMED1 Products (1)

mRNA Protein Name
NM_006858.4 NP_006849.1 transmembrane emp24 domain-containing protein 1 precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
8621446 GOA
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
12237308 GOA
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
12237308 GOA
located in endoplasmic reticulum-Golgi intermediate compartment IDA
IDA: Inferred from direct assay
12237308 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMED1 Protein Structure

EMP24_GP25L

EMP24_GP25L: emp24/gp25L/p24 family/GOLD (34 - 220)

  • 0
  • 100
  • 200
  • 227 a.a.
Protein Preferred Names Protein Names

transmembrane emp24 domain-containing protein 1

  • IL1RL1-binding protein

Recombinant TMED1 Proteins

Cat. No. Product Name Accession Purity
HY-P72445 TMED1 Protein, Human (HEK293, Fc) Q13445 (A24-N194) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P77240 TMED1 Protein, Human (HEK293, His) Q13445 (A24-N194) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Anemia, Congenital Dyserythropoietic, Type Iiia

  • Congenital Dyserythropoietic Anemia, Type Iii

  • Cdan3

  • Congenital Dyserythropoietic Anemia Type Iii

  • Cda Iii

  • Congenital Dyserythropoietic Anemia Type 3

  • CDAN3A

  • Dyserythropoietic Anemia, Congenital, Type Iiia

  • Cda, Type Iiia

  • Anemia, Congenital Dyserythropoietic, Type Iii

  • Anemia With Multinucleated Erythroblasts

  • Cda Type 3

  • Cda Type Iii

  • Dyserythropoietic Anemia, Congenital Type 3

  • Cda, Type Iii

  • Erythroreticulosis, Hereditary Benign

  • Anaemia With Multinucleated Erythroblasts

  • Congenital Dyserythropoietic Anaemia Type 3

  • Congenital Dyserythropoietic Anaemia Type Iii

  • Hereditary Benign Erythroreticulosis

  • Anemia, Congenital Dyserythropoietic, 3a

  • Anemia With Multinucleated Erythroblasts Erythroreticulosis, Hereditary Benign
Cystoisosporiasis

  • Isosporiasis

  • Infection By Isospora Belli And Isospora Hominis

  • Isosporosis

  • Infection By Isospora Belli Or Isospora Hominis

  • Isospora Belli Or Hominis Infection

  • Coccidial Infestation

  • Coccidiosis

  • Coccidial Dysentery

  • Intestinal Coccidiosis Nos
Anemia, Congenital Dyserythropoietic, Type Iv

  • CDAN4

  • Congenital Dyserythropoietic Anemia Type Iv

  • Congenital Dyserythropoietic Anemia Type 4

  • Cda Iv

  • Cda Due To Klf1 Mutation

  • Cda Type 4

  • Cda Type Iv

  • Congenital Dyserythropoietic Anemia Due To Klf1 Mutation

  • Cda, Type Iv

  • Dyserythropoietic Anemia, Congenital, Type Iv

  • Congenital Dyserythropoietic Anaemia Due To Klf1 Mutation

  • Congenital Dyserythropoietic Anaemia Type 4

  • Congenital Dyserythropoietic Anaemia Type Iv

  • Anemia, Congenital Dyserythropoietic, 4

  • Anemia, Dyserythropoietic Congenital, Type Iv

  • Anemia, Dyserythropoietic, Congenital, Type Iv
Noonan Syndrome 1

  • Noonan Syndrome

  • NS1

  • Male Turner Syndrome

  • Female Pseudo-Turner Syndrome

  • Turner Phenotype With Normal Karyotype

  • Noonan Syndrome With Pigmented Villonodular Synovitis

  • Turner'S Phenotype, Karyotype Normal

  • Familial Turner Syndrome

  • Noonan'S Syndrome

  • Noonan-Ehmke Syndrome

  • Ns

  • Pseudo-Ullrich-Turner Syndrome

  • Turner Syndrome In Female With X Chromosome

  • Turner-Like Syndrome

  • Ullrich-Noonan Syndrome

  • Noonan-Like/Multiple Giant Cell Lesion Syndrome

  • Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

  • Pterygium Colli Syndrome

  • Noonan Syndrome, Type 1

  • Turner Syndrome, Male
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14634 TMED1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19242 Tmed1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25731 Tmed1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TMED1 RGD RGD:1311679
Macaca mulatta TMED1 VGNC VGNC:79071
Bos taurus TMED1 VGNC VGNC:35934
Felis catus TMED1 VGNC VGNC:80736
Canis familiaris TMED1 VGNC VGNC:47436
Mus musculus TMED1 MGD MGI:106201
Others TMED1 NCBI