TSSK4 Protein, Human (Active, sf9, His, GST)

The TSSK4 protein is a critical serine/threonine kinase that is essential for male germ cell development and contributes to mature sperm function. It may participate in the Cre/Creb signaling pathway, phosphorylate CREB1 on "Ser-133" and stimulate this pathway. TSSK4 Protein, Human (sf9, His, GST) is the recombinant human-derived TSSK4 protein, expressed by sf9 insect cells , with N-8*His, N-GST labeled tag.

TSSK4, a serine/threonine kinase, plays a pivotal role in male germ cell development and contributes to mature sperm function. It is potentially involved in the Cre/Creb signaling pathway, as suggested by its ability to phosphorylate CREB1 on 'Ser-133' in vitro and stimulate the Cre/Creb pathway in cells. Additionally, TSSK4 exhibits phosphorylation activity on CREM at 'Ser-116' in vitro. Another target of TSSK4 phosphorylation is ODF2, with 'Ser-95' being a specific phosphorylation site. These findings underscore the multifaceted involvement of TSSK4 in critical cellular processes related to male germ cell development and sperm functionality.

Human

Sf9 insect cells

N-8*His;N-GST

Q6SA08 (G2-T328)

283629

Partial

GKGDVLEAAPTTTAYHSLMDEYGYEVGKAIGHGSYGSVYEAFYTKQKVMVAVKIISKKKASDDYLNKFLPREIQVMKVLRHKYLINFYRAIESTSRVYIILELAQGGDVLEWIQRYGACSEPLAGKWFSQLTLGIAYLHSKSIVHRDLKLENLLLDKWENVKISDFGFAKMVPSNQPVGCSPSYRQVNCFSHLSQTYCGSFAYACPEILRGLPYNPFLSDTWSMGVILYTLVVAHLPFDDTNLKKLLRETQKEVTFPANHTISQECKNLILQMLRQATKRATILDIIKDSWVLKFQPEQPTHEIRLLEAMCQLHNTTKQHQSLQITT

≥ 90%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.