ULBP4/RAET1E Protein, Human (HEK293, Fc)

ULBP4/RAET1E Protein crucially activates natural killer cell cytotoxicity by binding to and activating the KLRK1/NKG2D receptor. This interaction mediates cytotoxic responses, contributing to receptor activation and facilitating the recognition and targeting of marked cells for elimination. ULBP4/RAET1E's engagement with KLRK1/NKG2D underscores its significance in immune response regulation and natural killer cell activity modulation. ULBP4/RAET1E Protein, Human (HEK293, Fc) is the recombinant human-derived ULBP4/RAET1E protein, expressed by HEK293, with C-hFc labeled tag. The total length of ULBP4/RAET1E Protein, Human (HEK293, Fc) is 225 a.a., with molecular weight of ~49.1 kDa.

The ULBP4/RAET1E protein plays a crucial role in natural killer cell cytotoxicity by serving as a ligand that binds to and activates the KLRK1/NKG2D receptor. This interaction between ULBP4/RAET1E and KLRK1/NKG2D is pivotal in mediating the cytotoxic responses of natural killer cells. Through its binding affinity with KLRK1/NKG2D, ULBP4/RAET1E contributes to the activation of this receptor, facilitating the recognition and targeting of cells marked for elimination. The engagement of ULBP4/RAET1E with KLRK1/NKG2D underscores its significance in the regulation of immune responses and the modulation of natural killer cell activity.

Human

HEK293

C-hFc

Q8TD07 (M1-D225)

135250  [NCBI]

Approximately 49.1 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.