2. Gene
  3. RAET1E - retinoic acid early transcript 1E Gene

RAET1E - retinoic acid early transcript 1E Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as RL-4; LETAL; ULBP4; N2DL-4; NKG2DL4; RAET1E2; bA350J20.7

Gene ID: 135250 | Gene type: protein coding

About RAET1E

Cytogenetic location: 6q25.1 Genomic coordinates (GRCh38): 6:149,864,432-149,898,113 (from NCBI)

This gene has 6 transcripts (splice variants), 351 orthologues and 22 paralogues. Biased expression in esophagus (RPKM 7.0) and skin (RPKM 2.7).

Summary

This gene belong to the RAET1 family, which consists of major histocompatibility complex (MHC) class I-related genes located in a cluster on chromosome 6q24.2-q25.3. This and RAET1G protein differ from other RAET1 proteins in that they have type I membrane-spanning sequences at their C termini rather than glycosylphosphatidylinositol anchor sequences. This protein functions as a ligand for NKG2D receptor, which is expressed on the surface of several types of immune cells, and is involved in innate and adaptive immune responses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011]

RAET1E Products(6)

mRNA Protein Name
NM_001243325.2 NP_001230254.1 retinoic acid early transcript 1E isoform 2 precursor
NM_001243327.2 NP_001230256.1 retinoic acid early transcript 1E isoform 3 precursor
NM_001243328.3 NP_001230257.1 retinoic acid early transcript 1E isoform 4 precursor
NM_001394056.1 NP_001380985.1 retinoic acid early transcript 1E isoform 5 precursor
NM_001394057.1 NP_001380986.1 retinoic acid early transcript 1E isoform 1 precursor
NM_139165.3 NP_631904.1 retinoic acid early transcript 1E isoform 1 precursor

RAET1E Protein Structure

MHC_I_2

MHC_I_2: Class I Histocompatibility antigen, NKG2D ligand, domains 1 and 2 (31 - 197)

  • 0
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  • 200
  • 263 a.a.
Protein Preferred Names Protein Names

retinoic acid early transcript 1E

NKG2D ligand 4

Recombinant RAET1E Proteins

Cat. No. Product Name Accession Purity
HY-P76690 ULBP4/RAET1E Protein, Human (HEK293, Fc) Q8TD07 (M1-D225) ≥95%
HY-P76691 ULBP4/RAET1E Protein, Human (HEK293, His) Q8TD07-1 (H31-D225) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11618 RAET1E Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus RAET1E RGD RGD:1311118
Mus musculus RAET1E MGD MGI:1925027
Others RAET1E NCBI