RAET1E - retinoic acid early transcript 1E Gene

Also Known as RL-4; LETAL; ULBP4; N2DL-4; NKG2DL4; RAET1E2; bA350J20.7

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 135250

About RAET1E

Cytogenetic location: 6q25.1 Genomic coordinates (GRCh38): 6:149,864,432-149,898,113 (from NCBI)

This gene has 6 transcripts (splice variants), 351 orthologues and 22 paralogues. Biased expression in esophagus (RPKM 7.0) and skin (RPKM 2.7).

Summary

This gene belong to the RAET1 family, which consists of major histocompatibility complex (MHC) class I-related genes located in a cluster on chromosome 6q24.2-q25.3. This and RAET1G protein differ from Other RAET1 proteins in that they have type I membrane-spanning sequences at their C termini rather than glycosylphosphatidylinositol anchor sequences. This protein functions as a ligand for NKG2D receptor, which is expressed on the surface of several types of immune cells, and is involved in innate and adaptive immune responses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011]

RAET1E Products (6)

mRNA Protein Name
NM_001243325.2 NP_001230254.1 retinoic acid early transcript 1E isoform 2 precursor
NM_001243327.2 NP_001230256.1 retinoic acid early transcript 1E isoform 3 precursor
NM_001243328.3 NP_001230257.1 retinoic acid early transcript 1E isoform 4 precursor
NM_001394056.1 NP_001380985.1 retinoic acid early transcript 1E isoform 5 precursor
NM_001394057.1 NP_001380986.1 retinoic acid early transcript 1E isoform 1 precursor
NM_139165.3 NP_631904.1 retinoic acid early transcript 1E isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables natural killer cell lectin-like receptor binding IPI
IPI: Inferred from physical interaction
15240696 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18544572 GOA
Biological Process GO Annotation Evidence References Source
involved in natural killer cell mediated cytotoxicity IDA
IDA: Inferred from direct assay
15240696 GOA
involved in positive regulation of natural killer cell mediated cytotoxicity IDA
IDA: Inferred from direct assay
18544572 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAET1E Protein Structure

MHC_I_2

MHC_I_2: Class I Histocompatibility antigen, NKG2D ligand, domains 1 and 2 (31 - 197)

  • 0
  • 100
  • 200
  • 263 a.a.
Protein Preferred Names Protein Names

retinoic acid early transcript 1E

  • NKG2D ligand 4

RAET1E Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RAET1E Q8TD07 KLRK1 Homo sapiens P26718
SPR
28559451
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant RAET1E Proteins

Cat. No. Product Name Accession Purity
HY-P76690 ULBP4/RAET1E Protein, Human (HEK293, Fc) Q8TD07-1 (H31-D225) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P76691 ULBP4/RAET1E Protein, Human (HEK293, His) Q8TD07-1 (H31-D225) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11618 RAET1E Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20588 Raet1e Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27096 Raet1e Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus RAET1E RGD RGD:1311118
Mus musculus RAET1E MGD MGI:1925027
Others RAET1E NCBI