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  4. ULBP1/RAET1I Protein, Human (Biotinylated, HEK293, His-Avi)

ULBP1/RAET1I Protein, Human (Biotinylated, HEK293, His-Avi)

Cat. No.: HY-P78227
Handling Instructions

ULBP1/RAET1I Protein is crucial in natural killer cell cytotoxicity, binding to and activating the KLRK1/NKG2D receptor. This mechanism underscores ULBP1/RAET1I's significance in mediating cytotoxic responses. Notably, ULBP1/RAET1I does not bind beta2-microglobulin, emphasizing its specificity and selectivity in engaging KLRK1/NKG2D. This distinct interaction profile highlights ULBP1/RAET1I's pivotal role in immune responses and its potential as a therapeutic target for modulating natural killer cell activity. ULBP1/RAET1I Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived ULBP1/RAET1I protein, expressed by HEK293, with C-His, C-Avi labeled tag. The total length of ULBP1/RAET1I Protein, Human (Biotinylated, HEK293, His-Avi) is 190 a.a., with molecular weight of 28-35 kDa.

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Description

ULBP1/RAET1I Protein is crucial in natural killer cell cytotoxicity, binding to and activating the KLRK1/NKG2D receptor. This mechanism underscores ULBP1/RAET1I's significance in mediating cytotoxic responses. Notably, ULBP1/RAET1I does not bind beta2-microglobulin, emphasizing its specificity and selectivity in engaging KLRK1/NKG2D. This distinct interaction profile highlights ULBP1/RAET1I's pivotal role in immune responses and its potential as a therapeutic target for modulating natural killer cell activity. ULBP1/RAET1I Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived ULBP1/RAET1I protein, expressed by HEK293, with C-His, C-Avi labeled tag. The total length of ULBP1/RAET1I Protein, Human (Biotinylated, HEK293, His-Avi) is 190 a.a., with molecular weight of 28-35 kDa.
Background

The ULBP1/RAET1I protein plays a crucial role in natural killer cell cytotoxicity by acting as a ligand that binds to and activates the KLRK1/NKG2D receptor. This binding and activation mechanism highlights the significance of ULBP1/RAET1I in mediating the cytotoxic responses of natural killer cells. Moreover, it is noteworthy that ULBP1/RAET1I does not exhibit binding to beta2-microglobulin. This characteristic interaction profile underscores the specificity and selectivity of ULBP1/RAET1I in its engagement with KLRK1/NKG2D, emphasizing its pivotal role in immune responses and its potential as a therapeutic target for modulating natural killer cell activity.
Species

Human
Source

HEK293
Tag

C-His;C-Avi
Accession

Q9BZM6 (G26-P215)
Gene ID
Molecular Construction
N-term
ULBP1 (G26-P215)
Accession # Q9BZM6
His-Avi
C-term
Synonyms
ALCAN-beta; NKG2D ligand 1; N2DL-1; NKG2DL1; MULT-1; NKG2DL; AET1I; ULBP1; ULBP-1; ALCAN-β
Molecular Weight

28-35 kDa

Purity

Greater than 95% as determined by Tris-Bis PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

ULBP1/RAET1I Protein, Human (Biotinylated, HEK293, His-Avi) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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