ULBP1 - UL16 binding protein 1 Gene

Also Known as N2DL-1; RAET1I; NKG2DL1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 80329

About ULBP1

Cytogenetic location: 6q25.1 Genomic coordinates (GRCh38): 6:149,963,943-149,973,715 (from NCBI)

This gene has 1 transcript (splice variant), 454 orthologues and 22 paralogues. Biased expression in testis (RPKM 1.6), lung (RPKM 0.5) and 3 other tissues.

Summary

The protein encoded by this gene is a ligand of natural killer group 2, member D (NKG2D), an immune system-activating receptor on NK cells and T-cells. Binding of the encoded ligand to NKG2D leads to activation of several signal transduction pathways, including those of JAK2, STAT5, ERK and PI3K kinase/Akt. Also, in cytomegalovirus-infected cells, this ligand binds the UL16 glycoprotein and is prevented from activating the immune system. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

ULBP1 Products (2)

mRNA Protein Name
NM_001317089.2 NP_001304018.1 UL16-binding protein 1 isoform 2 precursor
NM_025218.4 NP_079494.1 UL16-binding protein 1 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables natural killer cell lectin-like receptor binding IDA
IDA: Inferred from direct assay
11239445 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28559451 GOA
enables receptor ligand activity IDA
IDA: Inferred from direct assay
15051759 GOA
Biological Process GO Annotation Evidence References Source
involved in natural killer cell activation IDA
IDA: Inferred from direct assay
11239445 GOA
involved in natural killer cell mediated cytotoxicity IDA
IDA: Inferred from direct assay
11239445 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
11239445 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ULBP1 Protein Structure

MHC_I

MHC_I: Class I Histocompatibility antigen, domains alpha 1 and 2 (39 - 203)

  • 0
  • 100
  • 200
  • 244 a.a.
Protein Preferred Names Protein Names

UL16-binding protein 1

  • NKG2D ligand 1

Recombinant ULBP1 Proteins

Cat. No. Product Name Accession Purity
HY-P71163 ULBP1/RAET1I Protein, Human (HEK293, His) Q9BZM6 (G26-P215) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72023 ULBP1/RAET1I Protein, Human (HEK293, Fc-Myc) Q9BZM6 (G26-G216) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P78227 ULBP1/RAET1I Protein, Human (Biotinylated, HEK293, His-Avi) Q9BZM6 (G26-P215) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P78535 ULBP1/RAET1I Protein, Human (HEK293, His-Avi) Q9BZM6 (G26-P215) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P700458 ULBP1/RAET1I Protein, Human (Biotinylated, HEK293, mFc-Avi) Q9BZM6 (G26-G216) ≥ 95%, as determined by reducing SDS-PAGE.

ULBP1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P87130 ULBP1 Antibody (YA6823) WB Human

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15448 ULBP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19245 Ulbp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25734 Ulbp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ULBP1 RGD RGD:7509852
Mus musculus ULBP1 MGD MGI:1925027
Others ULBP1 NCBI