VCAM-1/CD106 Protein, Mouse (HEK293, Fc)

VCAM-1/CD106 Protein, a cell adhesion molecule, is expressed on endothelial cells and plays a key role in leukocyte recruitment during inflammation. It interacts with integrins on leukocytes, facilitating their adhesion and migration across the blood vessel walls. VCAM-1/CD106 Protein is implicated in various inflammatory diseases and may serve as a potential therapeutic target for intervention. VCAM-1/CD106 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived VCAM-1/CD106 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of VCAM-1/CD106 Protein, Mouse (HEK293, Fc) is 674 a.a., with molecular weight of 100-130 kDa.

VCAM-1/CD106 protein is a cell adhesion glycoprotein primarily found on endothelial cells, and it plays a critical role in immune surveillance and inflammation. It serves as a key regulator of leukocyte adhesion to the endothelium by interacting with various integrins. During inflammatory responses, it binds to ligands on activated endothelial cells, subsequently initiating the activation of calcium channels and the plasma membrane-associated small GTPase RAC1, which in turn facilitates leukocyte transendothelial migration. Additionally, VCAM-1/CD106 protein acts as a quality-control checkpoint for entry into the bone marrow, providing a 'don't-eat-me' signal in the context of major histocompatibility complex (MHC) class-I presentation. Furthermore, in the case of microbial infection, it interacts with ECMV-D capsid proteins and functions as a receptor for this virus.

Mouse

HEK293

C-hFc

P29533 (F25-E698)

22329  [NCBI]

FKIEISPEYKTIAQIGDSMALTCSTTGCESPLFSWRTQIDSPLNAKVRTEGSKSVLTMEPVSFENEHSYLCTATCGSGKLERSIHVDIYSFPKDPEIQFSGPLEVGKPVTVKCLAPDIYPVYRLEIDLFKGDQLMNRQEFSSEEMTKSLETKSLEVTFTPVIEDIGKALVCRAKLHIDQIDSTLKERETVKELQVYISPRNTTISVHPSTRLQEGGAVTMTCSSEGLPAPEIFWGRKLDNEVLQLLSGNATLTLIAMRMEDSGVYVCEGVNLIGRDKAEVELVVQEKPFIVDISPGSQVAAQVGDSVVLTCAAIGCDSPSFSWRTQTDSPLNGVVRNEGAKSTLVLSSVGFEDEHSYLCAVTCLQRTLEKRTQVEVYSFPEDPVIKMSGPLVHGRPVTVNCTVPNVYPFDHLEIELLKGETTLMKKYFLEEMGIKSLETKILETTFIPTIEDTGKSLVCLARLHSGEMESEPKQRQSVQPLYVNVAPKETTIWVSPSPILEEGSPVNLTCSSDGIPAPKILWSRQLNNGELQPLSENTTLTFMSTKRDDSGIYVCEGINEAGISRKSVELIIQVSPKDIQLTVFPSKSVKEGDTVIISCTCGNVPETWIILKKKAKTGDMVLKSVDGSYTIRQAQLQDAGIYECESKTEVGSQLRSLTLDVKGKEHNKDYFSPE

100-130 kDa

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized powder.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.