2. Anti-infection
  3. Bacterial
  4. Rifabutin-vonoprazan conjugate 1

Rifabutin-vonoprazan conjugate 1 is an orally active acid-responsive bifunctional molecule. Rifabutin-vonoprazan conjugate 1 exhibits anti-Helicobacter pylori activity (MIC ≤ 0.125 μg/mL) and acid-suppressive effects (acid inhibition rate > 85% at a dose of 2 mg/kg). Rifabutin-vonoprazan conjugate 1 also demonstrates anti-ulcer activity. Rifabutin-vonoprazan conjugate 1 can be used in research related to Helicobacter pylori infection and gastric ulcer.

For research use only. We do not sell to patients.

Rifabutin-vonoprazan conjugate 1

Rifabutin-vonoprazan conjugate 1 Chemical Structure

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Rifabutin-vonoprazan conjugate 1 Related Antibodies

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Description

Rifabutin-vonoprazan conjugate 1 is an orally active acid-responsive bifunctional molecule. Rifabutin-vonoprazan conjugate 1 exhibits anti-Helicobacter pylori activity (MIC ≤ 0.125 μg/mL) and acid-suppressive effects (acid inhibition rate > 85% at a dose of 2 mg/kg). Rifabutin-vonoprazan conjugate 1 also demonstrates anti-ulcer activity. Rifabutin-vonoprazan conjugate 1 can be used in research related to Helicobacter pylori infection and gastric ulcer[1].

In Vitro

Rifabutin-vonoprazan conjugate 1 (Compound 10) (0.125-64 μg/mL; 48 h) inhibits H. pylori ATCC 700392, demonstrating activity comparable to rifabutin (HY-17025)[1].
Rifabutin-vonoprazan conjugate 1 (1 μM; 50 min) exhibitS a 9.66% inhibition rate against porcine gastric H+/K+-ATPase[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Rifabutin-vonoprazan conjugate 1 Related Antibodies
In Vivo

Rifabutin-vonoprazan conjugate 1 (2 mg/kg; oral gavage; single dose) inhibits gastric acid secretion in both the basal and stimulated models in SD rats[1].
Rifabutin-vonoprazan conjugate 1 (0.3-3 mg/kg; oral gavage; single dose) exhibits dose-dependent anti-ulcer activity in mice [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley (SD) (male, 250-280 g)[1]
Dosage: 2 mg/kg
Administration: i.g.; single dose
Result: Achieved 34.24% inhibition rate in basal gastric acid secretion model.
Achieved 64.97% inhibition rate in 2-Deoxy-D-glucose (HY-13966)-stimulated gastric acid secretion model.
Achieved 87.17% inhibition rate in Histamine (HY-B1204)-stimulated gastric acid secretion model.
Animal Model: Mice treated water-immersion
restraint stress[1]
Dosage: 0.3, 0.75, 1.5, and 3 mg/kg
Administration: i.g.; single dose
Result: Induced dose-dependent reduction in ulcer area between 0.3 and 1.5 mg/kg.
Showed most pronounced effect at 1.5 mg/kg, with antiulcer efficacy comparable to Vonoprazan (HY-100007) at 3 mg/kg.
Exacerbated ulcers at 3 mg/kg.
Molecular Weight

1972.51

Formula

C104H139FN10O21SSi2
SMILES

CC(C)[Si](C(C)C)(OCCCCCC1=CN(CCCCCCO[Si](C(C)C)(OC2=CC=C(COC(N(C)CC3=CN(S(=O)(C4=CC=CN=C4)=O)C(C5=CC=CC=C5F)=C3)=O)C=C2)C(C)C)N=N1)OC6=CC=C(COC(N7C8(CCN(CC(C)C)CC8)N=C(C7=C(NC(/C(C)=C\C=C\[C@H](C)[C@@H]([C@@H](C)[C@@H](O)[C@@H](C)[C@@H]([C@H](C)[C@@H](OC)/C=C/O9)OC(C)=O)O)=O)C%10=O)C%11=C%10C(O)=C(C)C(O[C@@]%129C)=C%11C%12=O)=O)C=C6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Rifabutin-vonoprazan conjugate 1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rifabutin-vonoprazan conjugate 1Bacterialgastric ulcerH. pylorirodent modelsmurine modelsSD ratsInhibitorinhibitorinhibit

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