2. GPCR/G Protein
  3. Trace Amine-associated Receptor (TAAR)
  4. RO 5073012

RO 5073012 is a selective, orally active and brain-penetrant TAAR1 agonist. RO 5073012 shows a Ki of 6 nM for hTAAR1 and EC50 values of 23 and 25 nM for mTAAR1 and rTAAR1. RO 5073012 can be used for the research of neurological disease, such as schizophrenia.

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RO 5073012

RO 5073012 화학구조

CAS No. : 1020814-70-3

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RO 5073012 Related Antibodies

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제품 설명

RO 5073012 is a selective, orally active and brain-penetrant TAAR1 agonist. RO 5073012 shows a Ki of 6 nM for hTAAR1 and EC50 values of 23 and 25 nM for mTAAR1 and rTAAR1. RO 5073012 can be used for the research of neurological disease, such as schizophrenia[1].

IC50 & Target

hTAAR1

6 nM (Ki)

mTAAR1

23 nM (EC50)

rTAAR1

25 nM (EC50)

Cellular Effect
Cell Line Type Value Description References
HEK293 EC50
23 nM
Compound: 24, Ro-5073012
Agonist activity at human TAAR1 receptor expressed in HEK293 cells after 30 mins
Agonist activity at human TAAR1 receptor expressed in HEK293 cells after 30 mins
[PMID: 22795332]
HEK293 EC50
23 nM
Compound: 24, Ro-5073012
Agonist activity at mouse TAAR1 receptor expressed in HEK293 cells after 30 mins
Agonist activity at mouse TAAR1 receptor expressed in HEK293 cells after 30 mins
[PMID: 22795332]
HEK293 EC50
25 nM
Compound: 24, Ro-5073012
Agonist activity at rat TAAR1 receptor expressed in HEK293 cells after 30 mins
Agonist activity at rat TAAR1 receptor expressed in HEK293 cells after 30 mins
[PMID: 22795332]
분자량

249.74

화학식

C13H16ClN3
CAS No.
SMILES

CC(N(C1=CC=C(Cl)C=C1)CC2=CN=CN2)C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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RO 5073012 Related Classifications

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  • 농도 희석 계산기

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RO 50730121020814-70-3RO5073012RO-5073012Trace Amine-associated Receptor (TAAR)Inhibitorinhibitorinhibit

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상품명:
RO 5073012
Cat. No.:
HY-117021
수량:
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