2. Anti-infection
  3. Bacterial
  4. RW3

RW3 (MP196) is a small cationic antimicrobial hexapeptide. RW3 targets the bacterial cytoplasmic membrane and inhibits cellular respiration and cell wall synthesis. RW3 exhibits high bioactivity against Gram-positive bacteria such as Bacillus subtilis 168 (MIC of 2 µg/mL). RW3 causes shrinking of murine erythrocytes. RW3 can be used in antimicrobial and antifungal research.

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RW3

RW3 構造式

CAS 番号 : 359632-11-4

容量 価格（税別） 在庫状況 数量
5 mg $60 在庫あり
10 mg $97 在庫あり
25 mg $175 在庫あり
50 mg $263 在庫あり
100 mg $395 在庫あり
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500 mg   お問い合わせ  

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RW3 関連抗体

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製品説明

RW3 (MP196) is a small cationic antimicrobial hexapeptide. RW3 targets the bacterial cytoplasmic membrane and inhibits cellular respiration and cell wall synthesis. RW3 exhibits high bioactivity against Gram-positive bacteria such as Bacillus subtilis 168 (MIC of 2 µg/mL). RW3 causes shrinking of murine erythrocytes. RW3 can be used in antimicrobial and antifungal research[1].

体外実験

RW3 (16 h) shows decent activity against Gram-positive bacteria like Bacillus subtilis 168 (MIC of 2 µg/mL) and some MRSA/VISA strains, but weak activity against Gram-negative bacteria such as Pseudomonas aeruginosa PA01 (MIC of >64 µg/mL)[1].
RW3 (0.09-200 µg/mL; 72 h) shows no significant cytotoxicity against NRK-52E rat kidney epithelial cells and CCRF-CEM human T-cell lymphoblast cells[1].
RW3 (10 ng-500 µg/mL; 1-24 h) does not induce NF-κB activation in RT4 bladder epithelial cells[1].
RW3 (250-500 µg/mL) causes shrinking of murine erythrocytes at 250 µg/mL and severe morphological changes plus lysis at 500 µg/mL, with 14% and 23% hemolysis respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RW3 関連抗体
体内実験

RW3 (5-25 mg/kg; i.v.) causes excitement and indisposition (recovered within 25 min) at 5-10 mg/kg, and hind limb paralysis plus death within minutes at 25 mg/kg in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1044.22

分子式

C51H69N19O6
CAS 番号
Appearance

Solid

Color

White to off-white

Sequence

Arg-Trp-Arg-Trp-Arg-Trp-NH2
Sequence Shortening

RWRWRW-NH2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Sealed storage, away from moisture
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 25 mg/mL (23.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9577 mL 4.7883 mL 9.5765 mL
5 mM 0.1915 mL 0.9577 mL 1.9153 mL
10 mM 0.0958 mL 0.4788 mL 0.9577 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9577 mL 4.7883 mL 9.5765 mL 23.9413 mL
5 mM 0.1915 mL 0.9577 mL 1.9153 mL 4.7883 mL
10 mM 0.0958 mL 0.4788 mL 0.9577 mL 2.3941 mL
15 mM 0.0638 mL 0.3192 mL 0.6384 mL 1.5961 mL
20 mM 0.0479 mL 0.2394 mL 0.4788 mL 1.1971 mL
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RW3 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RW3359632-11-4RW 3RW-3BacterialAntimicrobial and antifungalgram-positive bacteriaplasma membraneInhibitorinhibitorinhibit

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製品名:
RW3
製品番号:
HY-P10281
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