2. Neuronal Signaling Membrane Transporter/Ion Channel
  3. Amino Acid Decarboxylase GABA Receptor
  4. L-Allylglycine

L-Allylglycine  (Synonyms: L-2-Allylglycine)

Cat. No.: HY-W012906 Purity: 98.0%
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SDS
Handling Instructions Technical Support

L-Allylglycine (L-2-Allylglycine) is an amino acid derivative. L-Allylglycine is an inhibitor for glutamate decarboxylase (GAD) that reduces the GABA biosynthesis in the brain. L-Allylglycine exhibits convulsant activity.

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Custom Peptide Synthesis

CAS No. : 16338-48-0

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고객리뷰

Based on 1 publication(s) in Google Scholar

Other Forms of L-Allylglycine:

L-Allylglycine Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE L-Allylglycine

WB

    L-Allylglycine purchased from MedChemExpress. Usage Cited in: J Biol Chem. 2022 Dec;298(12):102603.  [Abstract]

    The effect of ACE2-mediated up-regulation of AKT phosphorylation is almost blocked by (S)-2-Allylglycine (Ally) (5 mM; 24 h) in HepG2 cells.

    • Biological Activity

    • 순도&문서

    • References

    • 고객리뷰

    제품 설명

    L-Allylglycine (L-2-Allylglycine) is an amino acid derivative. L-Allylglycine is an inhibitor for glutamate decarboxylase (GAD) that reduces the GABA biosynthesis in the brain. L-Allylglycine exhibits convulsant activity[1][2].

    In Vivo

    L-Allylglycine (150 mg/kg, ip or 200 μg, intranigral injection, single dose) induces convulsive behaviors in Sprague-Dawley rat models[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Sprague-Dawley rats models[2].
    Dosage: 150 mg/kg or 200 μg
    Administration: ip or intranigral injection, single dose
    Result: Reduced the GABA content in the hippocampus, cortex and cerebellum.
    Induced running fits, partial rigidity, and convulsions in rats.
    분자량

    115.13

    화학식

    C5H9NO2
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    선적

    Room temperature in continental US; may vary elsewhere.
    보관
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    용액&용해도
    In Vitro: 

    H2O : 50 mg/mL (434.29 mM; Need ultrasonic)

    DMSO : < 1 mg/mL (insoluble or slightly soluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 8.6858 mL 43.4292 mL 86.8583 mL
    5 mM 1.7372 mL 8.6858 mL 17.3717 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • 몰농도 계산기

    • 농도 희석 계산기

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    순도&문서

    Purity: ≥98.0%

    SDS (393 KB)

    COA (246 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 8.6858 mL 43.4292 mL 86.8583 mL 217.1458 mL
    5 mM 1.7372 mL 8.6858 mL 17.3717 mL 43.4292 mL
    10 mM 0.8686 mL 4.3429 mL 8.6858 mL 21.7146 mL
    15 mM 0.5791 mL 2.8953 mL 5.7906 mL 14.4764 mL
    20 mM 0.4343 mL 2.1715 mL 4.3429 mL 10.8573 mL
    25 mM 0.3474 mL 1.7372 mL 3.4743 mL 8.6858 mL
    30 mM 0.2895 mL 1.4476 mL 2.8953 mL 7.2382 mL
    40 mM 0.2171 mL 1.0857 mL 2.1715 mL 5.4286 mL
    50 mM 0.1737 mL 0.8686 mL 1.7372 mL 4.3429 mL
    60 mM 0.1448 mL 0.7238 mL 1.4476 mL 3.6191 mL
    80 mM 0.1086 mL 0.5429 mL 1.0857 mL 2.7143 mL
    100 mM 0.0869 mL 0.4343 mL 0.8686 mL 2.1715 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    L-Allylglycine Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    L-Allylglycine16338-48-0L-2-AllylglycineAmino Acid DecarboxylaseGABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorInhibitorinhibitorinhibit

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    상품명:
    L-Allylglycine
    Cat. No.:
    HY-W012906
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