2. Vitamin D Related/Nuclear Receptor
  3. Androgen Receptor
  4. S-23

S-23 is an orally active selective androgen receptor modulator (SARM) with a Ki of 1.7 nM. S-23 induces androgen receptor (AR)-mediated transcriptional activation in CV-1 cells. S-23 increases prostate, seminal vesicle, and levator ani muscle weights in castrated rats.

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S-23

S-23 Chemical Structure

CAS No. : 1010396-29-8

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
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Based on 1 publication(s) in Google Scholar

S-23 Related Antibodies

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1 Publications Citing Use of MCE S-23

  • Activité biologique

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Description

S-23 is an orally active selective androgen receptor modulator (SARM) with a Ki of 1.7 nM. S-23 induces androgen receptor (AR)-mediated transcriptional activation in CV-1 cells. S-23 increases prostate, seminal vesicle, and levator ani muscle weights in castrated rats[1][2].

IC50 & Target

Ki: 1.7 nM (Androgen receptor)[1]
In Vitro

S-23 induces AR-mediated transcriptional activation in CV-1 cells when used at a concentration of 10 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

S-23 Related Antibodies
In Vivo

By administration of S-23 to castrated animals, androgen-dependent organ weights increased in a dose-dependent manner. The ED50 of S-23 in the prostate and levator ani muscle is 0.43 and 0.079 mg/d, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague Dawley rats (in castrated male rats)[1]
Dosage: 0.01-3 mg
Administration: S.c.; daily for 14 d
Result: Androgen-dependent organ weights increased in a dose-dependent manner. At a dose rate as low as 0.1 mg/d, S-23 is able to selectively maintain the weight of the levator ani muscle at the intact control level, whereas its effects on the prostate and seminal vesicles are lower than 30% of those observed in intact controls.
Masse moléculaire

416.75

Formule

C18H13ClF4N2O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=CC=C(C#N)C(C(F)(F)F)=C1)[C@@](C)(O)COC2=CC=C(Cl)C(F)=C2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvant et solubilité
In Vitro: 

DMSO : 100 mg/mL (239.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3995 mL 11.9976 mL 23.9952 mL
5 mM 0.4799 mL 2.3995 mL 4.7990 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Calculateur de molarité

  • Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureté et documentation
Références

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3995 mL 11.9976 mL 23.9952 mL 59.9880 mL
5 mM 0.4799 mL 2.3995 mL 4.7990 mL 11.9976 mL
10 mM 0.2400 mL 1.1998 mL 2.3995 mL 5.9988 mL
15 mM 0.1600 mL 0.7998 mL 1.5997 mL 3.9992 mL
20 mM 0.1200 mL 0.5999 mL 1.1998 mL 2.9994 mL
25 mM 0.0960 mL 0.4799 mL 0.9598 mL 2.3995 mL
30 mM 0.0800 mL 0.3999 mL 0.7998 mL 1.9996 mL
40 mM 0.0600 mL 0.2999 mL 0.5999 mL 1.4997 mL
50 mM 0.0480 mL 0.2400 mL 0.4799 mL 1.1998 mL
60 mM 0.0400 mL 0.2000 mL 0.3999 mL 0.9998 mL
80 mM 0.0300 mL 0.1500 mL 0.2999 mL 0.7499 mL
100 mM 0.0240 mL 0.1200 mL 0.2400 mL 0.5999 mL
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S-23 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

S-231010396-29-8S23S 23Androgen ReceptortranscriptionalactivationCV-1cellscastratedprostateseminalvesiclelevatoranimuscleInhibitorinhibitorinhibit

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Nom du produit:
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