2. Neuronal Signaling
  3. Dopamine Transporter
  4. (S)-CE-123

(S)-CE-123 is a potent, selective, and novel atypical dopamine transporter (DAT) inhibitor with an EC50 of 2.76 μM in uptake inhibition assays conducted in HEK293 cells stably expressing human isoforms of DAT. (S)-CE-123, a Modafinil analogue, is able to penetrate the blood–brain barrier. (S)-CE-123 improves cognitive and motivational processes in experimental animals.

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(S)-CE-123

(S)-CE-123 Chemical Structure

CAS No. : 2378384-49-5

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(S)-CE-123 Related Antibodies

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Description

(S)-CE-123 is a potent, selective, and novel atypical dopamine transporter (DAT) inhibitor with an EC50 of 2.76 μM in uptake inhibition assays conducted in HEK293 cells stably expressing human isoforms of DAT. (S)-CE-123, a Modafinil analogue, is able to penetrate the blood–brain barrier. (S)-CE-123 improves cognitive and motivational processes in experimental animals[1][2].

In Vivo

(S)-CE-123 (6.0, 12.0, 24.0 mg/kg; ip; 30 min before testing) significantly attenuates the effects of TBZ (Tetrabenazine; HY-B0590) on lever pressing and chow intake. (S)-CE-123 alone has no significant difference with vehicle-treated rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Trained rats (adult male Sprague-Dawley rats)[1]
Dosage: 6.0, 12.0, 24.0 mg/kg
Administration: IP; 30 min before testing
Result: Attenuated the effects of TBZ (1.0 mg/kg) on lever pressing and chow intake.
Masse moléculaire

313.44

Formule

C17H15NOS2
CAS No.
SMILES

O=[S@@](CC1=CN=CS1)C(C2=CC=CC=C2)C3=CC=CC=C3
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvant et solubilité

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In Vivo:

The following protocol is derived from the literature and is for reference only. It is recommended to first try a small sample.

  • Protocol 1

    10% DMSO +15%Tween 80 +75% 0.9% saline

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(S)-CE-123 Related Classifications

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Keywords:

(S)-CE-1232378384-49-5Dopamine TransporterDATSLC6A3Atypicalblood–brain barriercognitivemotivationalInhibitorinhibitorinhibit

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