2378384-49-5
2378384-49-5
Chemical Structure
(S)-CE-123
- CAS No.: 2378384-49-5
- Formula:C17H15NOS2
- Molecular Weight:313.44
InChIKey: VBBBWHDWYLUSEL-NRFANRHFSA-N
SMILES: O=[S@@](CC1=CN=CS1)C(C2=CC=CC=C2)C3=CC=CC=C3
Biological Activity: (S)-CE-123 is a potent, selective, and novel atypical dopamine transporter (DAT) inhibitor with an EC50 of 2.76 μM in uptake inhibition assays conducted in HEK293 cells stably expressing human isoforms of DAT. (S)-CE-123, a Modafinil analogue, is able to penetrate the blood–brain barrier. (S)-CE-123 improves cognitive and motivational processes in experimental animals[1][2].
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(S)-CE-123 | (S)-CE-123 is a potent, selective, and novel atypical dopamine transporter (DAT) inhibitor with an EC50 of 2.76 μM in uptake inhibition assays conducted in HEK293 cells stably expressing human isoforms of DAT. (S)-CE-123, a Modafinil analogue, is able to penetrate the blood–brain barrier. (S)-CE-123 improves cognitive and motivational processes in experimental animals. | |||||||||||||||||||||
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References
- [1]. Renee A Rotolo, et al. The Novel Atypical Dopamine Uptake Inhibitor (S)-CE-123 Partially Reverses the Effort-Related Effects of the Dopamine Depleting Agent Tetrabenazine and Increases Progressive Ratio Responding. Front Pharmacol. 2019 Jun 28:10:682. [Content Brief]
- [2]. Eduardo R. Perez Gonzalez, et al. Process Development and Scale-Up of a Novel Atypical DAT Inhibitor (S)-CE-123. ACS Omega 2024, March 4.
Keywords
