2. Metabolic Enzyme/Protease
  3. Glycosidase Lipase
  4. Salacinol

Salacinol, compound found in Salacia reticulata, is an orally active α-glucosidase/lipase inhibitor. Salacinol inhibits enzymatic activity of intestinal maltase (IC50 = 3.2 μg/mL, Ki = 0.31 μg/mL), sucrase (IC50 = 0.84 μg/mL, Ki = 0.32 μg/mL), and isomaltase (IC50 = 0.59 μg/mL, Ki = 0.47 μg/mL), and inhibits increases in serum glucose levels in sucrose-loaded rats. Salacinol also inhibits pancreatic lipase and lipoprotein lipase. Salacinol can be used for the research of diabetes mellitus.

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Salacinol

Salacinol Estructura química

No. CAS : 200399-47-9

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Salacinol Related Antibodies

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Descripciòn

Salacinol, compound found in Salacia reticulata, is an orally active α-glucosidase/lipase inhibitor. Salacinol inhibits enzymatic activity of intestinal maltase (IC50 = 3.2 μg/mL, Ki = 0.31 μg/mL), sucrase (IC50 = 0.84 μg/mL, Ki = 0.32 μg/mL), and isomaltase (IC50 = 0.59 μg/mL, Ki = 0.47 μg/mL), and inhibits increases in serum glucose levels in sucrose-loaded rats. Salacinol also inhibits pancreatic lipase and lipoprotein lipase. Salacinol can be used for the research of diabetes mellitus[1][2].

IC50 & Target[1]

α‑glucosidase

 

Cellular Effect
Cell Line Type Value Description References
Caco-2 IC50
0.5 μM
Compound: 12, Salacinol
Inhibition of maltase in human Caco-2 cell membrane
Inhibition of maltase in human Caco-2 cell membrane
[PMID: 18258441]
In Vitro

Salacinol (300 mg/L; 30 min) significantly inhibits porcine pancreatic lipase activity by 12.6%[1].
Salacinol (100 mg/L; 2 h) significantly inhibits rat adipose tissue-derived lipoprotein lipase activity by 13.6%[1].
Salacinol (100 mg/L; 18 h) reduces remaining triglyceride content in rat epididymal fat-derived adipocytes to 75.3% of vehicle control[1].
Salacinol (30 min) competitively inhibits rat small intestinal brush border membrane vesicle maltase, sucrase, and isomaltase with IC50 values of 3.2, 0.84, and 0.59 μg/mL, respectively, and Ki values of 0.31, 0.32, and 0.47 μg/mL, respectively[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Salacinol Related Antibodies
In Vivo

Salacinol (1.3-10 mg/kg; p.o.) potently inhibits sucrose-induced serum glucose elevation in fasted male Wistar rats, with significant activity observed at oral doses as low as 1.3 mg/kg[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sucrose-induced sucrose-induced Wistar (male, weight 130-170 g)[2]
Dosage: 1.3 mg/kg; 2.5 mg/kg; 5 mg/kg; 10 mg/kg
Administration: p.o.
Result: Significantly inhibited the increase in serum glucose.
Peso molecular

334.36

Fòrmula

C9H18O9S2
No. CAS
SMILES

OC[C@@H]([C@@H](C[S@+]1[C@@H]([C@H]([C@@H](C1)O)O)CO)O)OS(=O)([O-])=O
Structure Classification
Initial Source
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
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Salacinol Related Classifications

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  • Do most proteins show cross-species activity?

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Keywords:

Salacinol200399-47-9GlycosidaseLipaseisomaltaserat small intestinal brush border membrane vesiclerat adipose tissue-derived lipoprotein lipasediabetes mellitussucraseporcine pancreatic lipaseSalacia reticulatarat intestinal maltaseα-glucosidaserat epididymal fat-derived adipocytesInhibitorinhibitorinhibit

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HY-119741
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