Salsolidine hydrochloride 

Salsolidine hydrochloride, a tetrahydroisoquinoline alkaloid, acts as a stereoselective competitive MAO A (monoamine oxidase A) inhibitor.

MAO A^[1]

Salsolidine hydrochloride is a tetrahydroisoquinoline alkaloid, acts as a stereoselective competitive MAO A inhibitor. The R-salsolidine is more active against MAO A than S-salsolidine (K_i=6 μM and 186 μM)^[1].
Salsolidine weakly inhibits the binding of δ-receptor, with a K_i of >100 μM^[2].
Salsolidine has the potential of inhibiting acetylcholinestearse and butyrylcholinesterase^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

243.73

C₁₂H₁₈ClNO₂

63283-42-1

CC1NCCC2=C1C=C(OC)C(OC)=C2.Cl

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Bembenek ME, et al. Inhibition of monoamine oxidases A and B by simple isoquinoline alkaloids: racemic and optically active 1,2,3,4-tetrahydro-, 3,4-dihydro-, and fully aromatic isoquinolines. J Med Chem. 1990 Jan;33(1):147-52.  [Content Brief]

  [2]. Airaksinen MM, et al. Binding of beta-carbolines and tetrahydroisoquinolines by opiate receptors of the delta-type. Acta Pharmacol Toxicol (Copenh). 1984 Nov;55(5):380-5.  [Content Brief]

  [3]. Tundis R, et al. A potential role of alkaloid extracts from Salsola species (Chenopodiaceae) in the treatment of Alzheimer's disease. J Enzyme Inhib Med Chem. 2009 Jun;24(3):818-24.  [Content Brief]