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SCH-1473759

HY-10482

(SCH1473759; SCH 1473759)

SCH-1473759

SCH-1473759 Chemical Structure

SCH 1473759 is a novel sub-nanomolar Aurora A/B inhibitor with IC50 of 4 nM and 13 nM, respectively.

Size Price Stock Quantity
10 mM * 1 mL in DMSO $206 In-stock
2 mg $120 In-stock
5 mg $220 In-stock
10 mg $320 In-stock
50 mg $750 Backordered
100 mg $1150 Backordered
200 mg Get quote
500 mg Get quote
For SCH-1473759, please see related products:  SCH-1473759 hydrochloride ,
Size Price Stock Quantity
10 mM * 1 mL in DMSO €202 In-stock
2 mg €118 In-stock
5 mg €216 In-stock
10 mg €314 In-stock
50 mg €735 Backordered
100 mg €1127 Backordered
200 mg Get quote
500 mg Get quote
For SCH-1473759, please see related products:  SCH-1473759 hydrochloride

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Inquiry Information
Product name: SCH-1473759
Cat. No.: HY-10482

SCH-1473759 Data Sheet

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    Purity: 98.20%

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    LCMS

Related Compound Libraries

Biological Activity of SCH-1473759

SCH 1473759 is a novel sub-nanomolar Aurora A/B inhibitor with IC50 of 4 nM and 13 nM, respectively.
IC50 Value: 4 nM (Aurora A); 13 nM (Aurora B)[1].
Target: Aurora Kinase
in vitro: Asynchronous cells required 24-h exposure to SCH 1473759 for maximal induction of >4 N DNA content and inhibition of cell growth. However, following taxane- or KSP inhibitor-induced mitotic arrest, less than 4-h exposure induced >4 N DNA content. This finding correlated with the ability of SCH 1473759 to accelerate exit from mitosis in response to taxane- and KSP inhibitor-induced arrest [2].
in vivo: SCH-1473759 showed efficacy and target engagement in A2780 human tumor xenograft model in mouse, and also acceptable pharmacokinetic dosing in dog, monkey and rodents, on target efficacy, as well as a safety profile in dogs[1].
Clinical trial: N/A
 

Chemical Information

M.Wt 426.54 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C20H26N8OS
CAS No 1094069-99-4
Solvent & Solubility

10 mM in DMSO

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 2.3444 mL 11.7222 mL 23.4445 mL
5 mM 0.4689 mL 2.3444 mL 4.6889 mL
10 mM 0.2344 mL 1.1722 mL 2.3444 mL

References on SCH-1473759

Other Forms

Inhibitor Kit

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