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Results for "

β-Amyloid (1-8)

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

4

Peptides

1

Natural
Products

Targets Recommended:
Cat. No. Nom du produit Target Áreas de investigación Chemical Structure
  • HY-P1047
    β-Sheet Breaker Peptide iAβ5

    [Pro18, Asp21] β-Amyloid (17-21)

    		 Amyloid-β Neurological Disease
    β-Sheet Breaker Peptide iAβ5 is an effective brain amyloid-β (Abeta) degrader. Abeta deposits are associated with Alzheimer's disease (AD), and the related toxicity arises from its β-sheet conformation and aggregation. β-Sheet Breaker Peptide iAβ5 can repeatedly induce the degradation of fibrillary amyloid deposits in vivo. Therefore, β-Sheet Breaker Peptide iAβ5 can prevent and/or reverse neuronal contraction caused by Abeta and reduce the range of interleukin IL-1beta positive microglial-like cells around Abeta deposits. β-Sheet Breaker Peptide iAβ5 can reduce the size and/or number of brain amyloid plaques in AD. β-Sheet Breaker Peptide iAβ5 is labeled with a hydrophobic benzyl alcohol (HBA) tag and shows a bright blue color under acidic conditions, which can be used for quantitative determination.
    β-Sheet Breaker Peptide iAβ5
  • HY-100275
    MK-3328

    		Amyloid-β Neurological Disease
    MK-3328 is a β-Amyloid ligand, which exhibits high binding potency with an IC50 of 10.5 nM. MK-3328 is capable of being labelled with 18F for positron emission tomography (PET) imaging .
    MK-3328
  • HY-P5946
    β-Amyloid (1-8)

    		Amyloid-β Others
    β-Amyloid (1-8) is aAβ Fragment.
    β-Amyloid (1-8)
  • HY-P1879
    β-Amyloid (18-28)

    		Amyloid-β Neurological Disease
    β-Amyloid (18-28) is a peptide fragment of β-Amyloid.
    β-Amyloid (18-28)
  • HY-P5945
    β-Amyloid (1-8, A2V)

    		Amyloid-β Neurological Disease
    β-Amyloid (1-8, A2V) is amutantion of β-Amyloid (1-8) (HY-P5946).
    β-Amyloid (1-8, A2V)
  • HY-151554
    SQ-3

    		Amyloid-β Others
    SQ-3 is a quinoline analogue, displays moderate selectivity for α-syn aggregates (Ki=39.3 nM) over β-amyloid (Aβ) aggregates (Ki=230 nM). [ 18F]SQ3 has basic properties as a lead compound for the development of a useful α-syn imaging probe .
    SQ-3
  • HY-157441
    AChE/Aβ-IN-4

    		Cholinesterase (ChE) Amyloid-β Neurological Disease
    AChE/Aβ-IN-4 is a dual inhibitor of acetylcholinesterase (AChE) and β-amyloid (Aβ) aggregation, with the IC50 values of 1.72 ± 0.18 μM and 1.42 ± 0.3 μM, respectively. AChE/Aβ-IN-4 plays an impotant role in neurological disorders, such as Alzheimer’s disease .
    AChE/Aβ-IN-4
  • HY-N13064
    2,2′,4,4′-Tetrahydroxychalcone

    		Drug Derivative Beta-secretase Amyloid-β Neurological Disease
    2,2′,4,4′-Tetrahydroxychalcone (Compound 18) is a selective and potent BACE1 inhibitor with an IC50 of 0.62 μM. 2,2′,4,4′-Tetrahydroxychalcone is a derivative of Isoliquiritigenin (HY-N0102) found in Glycyrrhiza uralensis. 2,2′,4,4′-Tetrahydroxychalcone can block the β-cutting step of amyloid precursor protein (APP), thereby reducing the production of β-amyloid (Aβ) peptide. 2,2′,4,4′-Tetrahydroxychalcone can be used for research of Alzheimer’s disease .
    2,2′,4,4′-Tetrahydroxychalcone

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