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Results for "

11088-09-8

" in MedChemExpress (MCE) Product Catalog:

By Targets:	JAK (1) Reference Standards (1) STAT (1) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (1) Cardiovascular Disease (1) Inflammation/Immunology (1)

Inhibitors & Agonists

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Wilforine	JAK STAT Wnt β-catenin	Inflammation/Immunology Cancer
Wilforine is an orally active JAK-STAT pathway inhibitor with immunomodulatory effects and the ability to inhibit osteoclast fusion. Wilforine disrupts lipid raft integrity, reprograms cholesterol and glycosphingolipid metabolic pathways, regulates NF-κB and the complement system, and modulates the expression of various interleukins. Wilforine also inhibits the Wnt11/β-catenin signaling pathway and suppresses the proliferation of fibroblast-like synoviocytes. Wilforine can serve as a quality and pharmacokinetic marker for Tripterygium glycoside tablets, and can be applied to research on related diseases such as rheumatoid arthritis, inflammatory osteolysis, and SAPHO syndrome .

Wilforine (Standard)	Reference Standards Others	Cardiovascular Disease
Wilforine (Standard) is the analytical standard of Wilforine. This product is intended for research and analytical applications.

Wilforine	Cardiovascular Disease Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Celastraceae Tripterygium wilfordii Hook. f. Plants Disease Research Fields Source Classification	JAK STAT Wnt β-catenin
Wilforine is an orally active JAK-STAT pathway inhibitor with immunomodulatory effects and the ability to inhibit osteoclast fusion. Wilforine disrupts lipid raft integrity, reprograms cholesterol and glycosphingolipid metabolic pathways, regulates NF-κB and the complement system, and modulates the expression of various interleukins. Wilforine also inhibits the Wnt11/β-catenin signaling pathway and suppresses the proliferation of fibroblast-like synoviocytes. Wilforine can serve as a quality and pharmacokinetic marker for Tripterygium glycoside tablets, and can be applied to research on related diseases such as rheumatoid arthritis, inflammatory osteolysis, and SAPHO syndrome .

Wilforine (Standard)	Structural Classification Terpenoids Sesquiterpenes Celastraceae Tripterygium wilfordii Hook. f. Plants Source Classification	Reference Standards Others
Wilforine (Standard) is the analytical standard of Wilforine. This product is intended for research and analytical applications.

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