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14+15+eet

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By Targets:	Bacterial (1) Biochemical Assay Reagents (1) Cytochrome P450 (2) Drug Derivative (3) Endogenous Metabolite (4) Isotope-Labeled Compounds (3) Mitosis (2)
By Research Areas:	Cancer (3) Cardiovascular Disease (6) Infection (1) Inflammation/Immunology (1) Metabolic Disease (1) Neurological Disease (1)

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Natural
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Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-113489

14,15-Epoxyeicosatrienoic acid 14,15-EET	Endogenous Metabolite	Cardiovascular Disease Neurological Disease
14,15-Epoxyeicosatrienoic acid (14,15-EET) is a metabolite of Arachidonic acid (HY-109590). 14,15-Epoxyeicosatrienoic acid is a potent inhibitor of in vivo platelet aggregation. 14,15-Epoxyeicosatrienoic acid facilitates astrocytic Aβ clearance. 14,15-Epoxyeicosatrienoic acid can be used for Alzheimer's Disease research .

HY-150084

(±)14,15-Epoxyeicosatrienoic acid (±)14(15)-EET	Cytochrome P450 Mitosis	Cancer
(±)14,15-Epoxyeicosatrienoic acid ((±)14(15)-EET) is the Cytochrome P450 metabolite of arachidonic acid. While CYP3A4 may be involved in breast cancer cell growth, (±)14,15-Epoxyeicosatrienoic acid may promote mitosis and anchorage-dependent cloning through STAT3 affected by CYP3A4. (±)14,15-Epoxyeicosatrienoic acid exhibits STAT3-dependent cell growth promotion and may also participate in the autocrine/paracrine pathway that drives cell growth .

HY-139961S

*(±)14(15)-EET-d11*	Isotope-Labeled Compounds	Others
(±)14(15)-EET-d₁₁ is the deuterium labeled (±)14(15)-EET .

HY-120954

14,15-EE-5(Z)-E 1 Publications Verification	Endogenous Metabolite	Cardiovascular Disease
14,15-EE-5(Z)-E is a structural analogue of 14, 15-epoxide dicartrienoic acid (14,15-EET). 14,15-EE-5(Z)-E antagonizes the relaxation of vascular smooth muscle induced by EET .

HY-139937S

*(±)14(15)-EET-d11 methyl ester*	Isotope-Labeled Compounds	Others
(±)14(15)-EET-d₁₁ methyl ester is the deuterium labeled (±)14(15)-EET methyl ester .

HY-131721

14,15-EET-SI	Drug Derivative Mitosis	Others
14,15-EET-SI is a sulfonimide (SI) analog metabolized from 14,15-EET, which is also an effective mitogen. 14,15-EET-SI can stimulate the incorporation of [3H] thymidine, activate pp60c-src and initiate the tyrosine kinase cascade, mediating their mitotic effects. Additionally, 14,15-EET-SI can increase cell proliferation as well as the expression of c-fos and egr-1 mRNA .

HY-165005A

*(±)14(15)-EET* Methyl ester**	Drug Derivative	Cardiovascular Disease
(±) 14 (15)-EET Methyl ester (Compound 14,15-EET-Me) is a 14,15-EET (HY-113489) analog and vasodilatory agonist. (±) 14 (15)-EET Methyl ester induces relaxation of precontracted bovine coronary arteries .

HY-175044

*(±)14(15)-EET* Ethanolamide** (±)14(15)-Epoxy eicosatrienoyl ethanolamide	Bacterial	Infection Inflammation/Immunology
(±)14(15)-EET Ethanolamide ((±)14(15)-Epoxy eicosatrienoyl ethanolamide) is a fatty acid monoepoxide. (±)-14(15)-EET ethanolamide can be used in the research of Pseudomonas aeruginosa infections and respiratory diseases .

HY-143664

(±)14(15)-DiHET (±)14,15-DiHETrE	Endogenous Metabolite	Cardiovascular Disease
(±)14(15)-DiHET ((±)14,15-DiHETrE) is an epoxide hydrolases enzymatically hydrated metabolite of (±)14(15)-EET .

HY-CE00870

14,15-EET-CoA 14,15-Epoxy-(5Z,8Z,11Z)-eicosatrienoyl-coenzyme A	Biochemical Assay Reagents	Metabolic Disease
14,15-EET-CoA (14,15-Epoxy-(5Z,8Z,11Z)-eicosatrienoyl-coenzyme A) is an unsaturated fatty acyl-CoA.

HY-143664S

(±)14(15)-DiHET-d11 (±)14,15-DiHETrE-d₁₁	Isotope-Labeled Compounds Endogenous Metabolite	Cardiovascular Disease
(±)14,15-DiHETrE-d₁₁ ((±)14(15)-DiHET-d₁₁) is the deuterium labeled (±)14,15-DiHETrE (HY-143664). (±)14,15-DiHETrE is an epoxide hydrolases enzymatically hydrated metabolite of (±)14(15)-EET .

HY-165067

14,15-EE-8(Z)-E 14,15-Epoxyeicosa-8(Z)-enoic acid	Drug Derivative	Cardiovascular Disease
14,15-EE-8(Z)-E (14,15-Epoxyeicosa-8(Z)-enoic acid) has potent vasodilator agonist activity in bovine coronary arteries. 14,15-EE-8(Z)-E is a 14,15-EET (HY-113489) analog. EETs represent important mediators of coronary vascular tone .

HY-139002

CYP4Z1-IN-2	Cytochrome P450	Cancer
CYP4Z1-IN-2 (compound 7) is a reversible inhibitor of CYP4Z1 (K_i=2.2 μM), which inhibits the production of 14,15-EET in breast cancer cells. CYP4Z1-IN-2 inhibits the CYP4Z1-mediated Luc-BE O-debenzylation reaction with an IC₅₀ of 5.9 μM .

HY-N12970

14S(15R)-EET	Others	Others
14S(15R)-EET is an endogenous epoxytrienoic acid derivative that mainly exists in rat organs. By studying its metabolic process, it was found that its stereoselective hydration and formation of chiral diols were significantly affected by epoxidase. Different 14,15-EET enantiomers showed different regions and stereochemistry of hydration reactions, among which 14(R),15(S)-EET showed specific hydration for C15. These findings reveal the important role of epoxidase in the metabolism of endogenous EETs, and the differences in enzyme affinity and reaction rate for individual EET enantiomers may lead to their stereoselective metabolism .

HY-183844

C5F2-HCB		Cancer
C5F2-HCB is a CYP-mediated inhibitor of the biosynthesis of arachidonic acid epoxygenase product (±) 14,15-EET (HY-150084), with an IC₅₀ of 3.1 μM. C5F2-HCB inhibits EET-driven oxidative phosphorylation (OXPHOS) associated with tumor hypoxia, converting an immunologically "cold" tumor microenvironment into a "hot" one. C5F2-HCB reverses the immune-excluded tumor microenvironment in ER ⁺HER2 ⁻ breast cancer allograft models. C5F2-HCB can be used in research related to ER ⁺HER2 ⁻ breast cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-150084

(±)14,15-Epoxyeicosatrienoic acid (±)14(15)-EET	Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Cytochrome P450 Mitosis
(±)14,15-Epoxyeicosatrienoic acid ((±)14(15)-EET) is the Cytochrome P450 metabolite of arachidonic acid. While CYP3A4 may be involved in breast cancer cell growth, (±)14,15-Epoxyeicosatrienoic acid may promote mitosis and anchorage-dependent cloning through STAT3 affected by CYP3A4. (±)14,15-Epoxyeicosatrienoic acid exhibits STAT3-dependent cell growth promotion and may also participate in the autocrine/paracrine pathway that drives cell growth .

HY-N12970

14S(15R)-EET	Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Others
14S(15R)-EET is an endogenous epoxytrienoic acid derivative that mainly exists in rat organs. By studying its metabolic process, it was found that its stereoselective hydration and formation of chiral diols were significantly affected by epoxidase. Different 14,15-EET enantiomers showed different regions and stereochemistry of hydration reactions, among which 14(R),15(S)-EET showed specific hydration for C15. These findings reveal the important role of epoxidase in the metabolism of endogenous EETs, and the differences in enzyme affinity and reaction rate for individual EET enantiomers may lead to their stereoselective metabolism .

Cat. No.	Product Name	Chemical Structure

HY-139961S

*(±)14(15)-EET-d11*
(±)14(15)-EET-d₁₁ is the deuterium labeled (±)14(15)-EET .

HY-139937S

*(±)14(15)-EET-d11 methyl ester*
(±)14(15)-EET-d₁₁ methyl ester is the deuterium labeled (±)14(15)-EET methyl ester .

HY-143664S

(±)14(15)-DiHET-d11
(±)14,15-DiHETrE-d₁₁ ((±)14(15)-DiHET-d₁₁) is the deuterium labeled (±)14,15-DiHETrE (HY-143664). (±)14,15-DiHETrE is an epoxide hydrolases enzymatically hydrated metabolite of (±)14(15)-EET .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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14+15+eet

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Natural
Products