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Cat. No.: HY-183844

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C5F2-HCB

C5F2-HCB is a CYP-mediated inhibitor of the biosynthesis of arachidonic acid epoxygenase product (±) 14,15-EET (HY-150084), with an IC₅₀ of 3.1 μM. C5F2-HCB inhibits EET-driven oxidative phosphorylation (OXPHOS) associated with tumor hypoxia, converting an immunologically "cold" tumor microenvironment into a "hot" one. C5F2-HCB reverses the immune-excluded tumor microenvironment in ER⁺HER2⁻ breast cancer allograft models. C5F2-HCB can be used in research related to ER⁺HER2⁻ breast cancer.

For research use only. We do not sell to patients.

CAS No.: 2792206-44-9
Formula: C₁₇H₂₅F₂N₅
Molecular Weight:337.41

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Please store the product under the recommended conditions in the Certificate of Analysis.

C5F2-HCB Chemical Structure

CAS No.: 2792206-44-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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- In Vivo
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Biological Activity

Description

In Vivo

C5F2-HCB (18 mg/kg; once daily) inhibits the growth of ER⁺HER2^- SSM2ucd breast cancer xenografts to 49.6-53.3% of the control level, and modulates an immune-repulsive tumor microenvironment by increasing CD8⁺ tumor-infiltrating lymphocytes (TILs), reducing intratumoral regulatory T cells (Tregs), decreasing macrophage numbers and the M2/M1 macrophage ratio, and increasing intratumoral neutrophils^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2792206-44-9
Molecular Weight 337.41
Formula C₁₇H₂₅F₂N₅
SMILES

N=C(NC(NCCCCC(F)(F)C)=N)NCC12[C@H]3[C@H]4[C@@H]1[C@@H]5C4[C@H]3[C@@H]52
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Guo Z, et al. Abstract LB010: C5F2-hexyl-(cuban-1-yl-methyl)-biguanide (C5F2-HCB) overcomes an immune excluded tumor microenvironment (TME) and suppresses tumor growth in the ovarian dependent ER+ HER2-SSM2ucd mammary carcinoma allograft model. Cancer Research. 2025 Apr 25;85(8_Supplement_2):LB010-.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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