2. C5F2-HCB

C5F2-HCB is a CYP-mediated inhibitor of the biosynthesis of arachidonic acid epoxygenase product (±) 14,15-EET (HY-150084), with an IC50 of 3.1 μM. C5F2-HCB inhibits EET-driven oxidative phosphorylation (OXPHOS) associated with tumor hypoxia, converting an immunologically "cold" tumor microenvironment into a "hot" one. C5F2-HCB reverses the immune-excluded tumor microenvironment in ER+HER2− breast cancer allograft models. C5F2-HCB can be used in research related to ER+HER2− breast cancer.

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C5F2-HCB

C5F2-HCB Chemical Structure

CAS No. : 2792206-44-9

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C5F2-HCB Related Antibodies

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Description

C5F2-HCB is a CYP-mediated inhibitor of the biosynthesis of arachidonic acid epoxygenase product (±) 14,15-EET (HY-150084), with an IC50 of 3.1 μM. C5F2-HCB inhibits EET-driven oxidative phosphorylation (OXPHOS) associated with tumor hypoxia, converting an immunologically "cold" tumor microenvironment into a "hot" one. C5F2-HCB reverses the immune-excluded tumor microenvironment in ER+HER2− breast cancer allograft models. C5F2-HCB can be used in research related to ER+HER2− breast cancer[1].

In Vivo

C5F2-HCB (18 mg/kg; once daily) inhibits the growth of ER+HER2- SSM2ucd breast cancer xenografts to 49.6-53.3% of the control level, and modulates an immune-repulsive tumor microenvironment by increasing CD8+ tumor-infiltrating lymphocytes (TILs), reducing intratumoral regulatory T cells (Tregs), decreasing macrophage numbers and the M2/M1 macrophage ratio, and increasing intratumoral neutrophils[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

337.41

Formula

C17H25F2N5
CAS No.
SMILES

N=C(NC(NCCCCC(F)(F)C)=N)NCC12[C@H]3[C@H]4[C@@H]1[C@@H]5C4[C@H]3[C@@H]52
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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C5F2-HCB Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

C5F2-HCB2792206-44-9CD8+ tumor-infiltrating lymphocytesmacrophagesanti-PD-1regulatory T cells(±)14,15-EETcytochrome P450 monooxygenaseneutrophilsER+HER2- mammary carcinomaM2/M1 macrophage ratiooxidative phosphorylationInhibitorinhibitorinhibit

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