2792206-44-9
Chemical Structure
C5F2-HCB
- CAS No.: 2792206-44-9
- Formula:C17H25F2N5
- Molecular Weight:337.41
InChIKey: OZYANZYZBBXRSO-DDLIFRIDSA-N
SMILES: N=C(NC(NCCCCC(F)(F)C)=N)NCC12[C@H]3[C@H]4[C@@H]1[C@@H]5C4[C@H]3[C@@H]52
Biological Activity: C5F2-HCB is a CYP-mediated inhibitor of the biosynthesis of arachidonic acid epoxygenase product (±) 14,15-EET (HY-150084), with an IC50 of 3.1 μM. C5F2-HCB inhibits EET-driven oxidative phosphorylation (OXPHOS) associated with tumor hypoxia, converting an immunologically "cold" tumor microenvironment into a "hot" one. C5F2-HCB reverses the immune-excluded tumor microenvironment in ER+HER2− breast cancer allograft models. C5F2-HCB can be used in research related to ER+HER2− breast cancer[1].
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C5F2-HCB | C5F2-HCB is a CYP-mediated inhibitor of the biosynthesis of arachidonic acid epoxygenase product (±) 14,15-EET (HY-150084), with an IC50 of 3.1 μM. C5F2-HCB inhibits EET-driven oxidative phosphorylation (OXPHOS) associated with tumor hypoxia, converting an immunologically "cold" tumor microenvironment into a "hot" one. C5F2-HCB reverses the immune-excluded tumor microenvironment in ER+HER2− breast cancer allograft models. C5F2-HCB can be used in research related to ER+HER2− breast cancer. | |||||||||||||||||||||
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