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17-AAG

" in MedChemExpress (MCE) Product Catalog:

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製品番号 製品名 Target 研究分野 構造式
  • HY-10211
    Tanespimycin
    65+ Cited Publications

    17-AAG; NSC 330507; CP 127374

    		 HSP Autophagy Mitophagy Bacterial Apoptosis Antibiotic Infection Cancer
    Tanespimycin (17-AAG) is a potent HSP90 inhibitor with an IC50 of 5 nM, having a 100-fold higher binding affinity for tumour cell derived HSP90 than normal cell derived HSP90 . Tanespimycin depletes cellular STK38/NDR1 and reduces STK38 kinase activity. Tanespimycin also downregulates the stk38 gene expression .
    Tanespimycin
  • HY-124653
    HSP27 inhibitor J2
    5+ Cited Publications

    J2

    		 HSP Cancer
    HSP27 inhibitor J2 (J2) is a HSP27 inhibitor, which significantly induces abnormal HSP27 dimer formation and inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the HSP27 and reducing a cell protection function thereof. HSP27 inhibitor J2 (J2) remarkably enhances the antiproliferative activity of 17-AAG and sensitizes cisplatin-induced lung cancer cell growth inhibition .
    HSP27 inhibitor J2
  • HY-10211R
    Tanespimycin (Standard)

    17-AAG (Standard); NSC 330507 (Standard); CP 127374 (Standard)

    		 Reference Standards HSP Autophagy Mitophagy Bacterial Apoptosis Antibiotic Infection Cancer
    Tanespimycin (Standard) is the analytical standard of Tanespimycin. This product is intended for research and analytical applications. Tanespimycin (17-AAG) is a potent HSP90 inhibitor with an IC50 of 5 nM, having a 100-fold higher binding affinity for tumour cell derived HSP90 than normal cell derived HSP90 . Tanespimycin depletes cellular STK38/NDR1 and reduces STK38 kinase activity. Tanespimycin also downregulates the stk38 gene expression .
    Tanespimycin (Standard)
  • HY-10211S
    Tanespimycin-d5

    17-AAG-d5; NSC 330507-d5; CP 127374-d5

    		 Isotope-Labeled Compounds Apoptosis Bacterial Autophagy HSP Mitophagy Antibiotic Cancer
    Tanespimycin-d5 (17-AAG-d5; NSC 330507-d5; CP 127374-d5) is the deuterium labeled Tanespimycin (HY-10211). Tanespimycin (17-AAG) is a potent HSP90 inhibitor with an IC50 of 5 nM, having a 100-fold higher binding affinity for tumour cell derived HSP90 than normal cell derived HSP90 . Tanespimycin depletes cellular STK38/NDR1 and reduces STK38 kinase activity. Tanespimycin also downregulates the stk38 gene expression .
    Tanespimycin-d5

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