1. Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
  2. HSP
  3. HSP27 inhibitor J2

HSP27 inhibitor J2 (Synonyms: J2)

Cat. No.: HY-124653 Purity: 98.57%
Handling Instructions

HSP27 inhibitor J2 (J2) is a HSP27 inhibitor, which significantly induces abnormal HSP27 dimer formation and inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the HSP27 and reducing a cell protection function thereof. HSP27 inhibitor J2 (J2) remarkably enhances the antiproliferative activity of 17-AAG and sensitizes cisplatin-induced lung cancer cell growth inhibition.

For research use only. We do not sell to patients.

HSP27 inhibitor J2 Chemical Structure

HSP27 inhibitor J2 Chemical Structure

CAS No. : 2133499-85-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 581 In-stock
Estimated Time of Arrival: December 31
1 mg USD 200 In-stock
Estimated Time of Arrival: December 31
5 mg USD 400 In-stock
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1000 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Description

HSP27 inhibitor J2 (J2) is a HSP27 inhibitor, which significantly induces abnormal HSP27 dimer formation and inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the HSP27 and reducing a cell protection function thereof. HSP27 inhibitor J2 (J2) remarkably enhances the antiproliferative activity of 17-AAG and sensitizes cisplatin-induced lung cancer cell growth inhibition[1][2].

IC50 & Target

HSP27[2]

Molecular Weight

264.30

Formula

C₁₃H₁₂O₄S

CAS No.

2133499-85-9

SMILES

O=C1C=C(C)OC2=C1C(O)=CC(OCC3SC3)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (94.59 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7836 mL 18.9179 mL 37.8358 mL
5 mM 0.7567 mL 3.7836 mL 7.5672 mL
10 mM 0.3784 mL 1.8918 mL 3.7836 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (9.46 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

HSP27 inhibitor J2J2J 2J-2HSPHeat shock proteinsInhibitorinhibitorinhibit

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Product name:
HSP27 inhibitor J2
Cat. No.:
HY-124653
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