2133499-85-9
Chemical Structure
HSP27 inhibitor J2
Synonym(s): J2
- CAS. Nr.: 2133499-85-9
- Formula:C13H12O4S
- Molecular Weight:264.30
IUPAC Name: 5-hydroxy-2-methyl-7-(thiiran-2-ylmethoxy)-4H-chromen-4-one
InChIKey: VDCWAGBPDCXRDU-UHFFFAOYSA-N
SMILES: O=C1C=C(C)OC2=C1C(O)=CC(OCC3SC3)=C2
Biological Activity: HSP27 inhibitor J2 (J2) is a HSP27 inhibitor, which significantly induces abnormal HSP27 dimer formation and inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the HSP27 and reducing a cell protection function thereof. HSP27 inhibitor J2 (J2) remarkably enhances the antiproliferative activity of 17-AAG and sensitizes cisplatin-induced lung cancer cell growth inhibition[1][2].
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HSP27 inhibitor J2 | 99.70% | HSP27 inhibitor J2 (J2) is a HSP27 inhibitor, which significantly induces abnormal HSP27 dimer formation and inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the HSP27 and reducing a cell protection function thereof. HSP27 inhibitor J2 (J2) remarkably enhances the antiproliferative activity of 17-AAG and sensitizes cisplatin-induced lung cancer cell growth inhibition. | ||||||||||||||||||||
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Keywords
