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34539-65-6

" in MedChemExpress (MCE) Product Catalog:

2

阻害剤およびアゴニスト

2

天然物

製品番号 製品名 Target 研究分野 構造式
  • HY-N5112A
    β,β-Dimethylacrylalkannin
    3 Publications Verification

    Arnebin 1

    		 FGFR Necroptosis Apoptosis CDK JNK Inflammation/Immunology
    β,β-Dimethylacrylalkannin (Arnebin 1) is an orally active FGFR1 inhibitor (IC50=2.5 μM) and the main active component of Lithospermum erythrorhizon. β,β-Dimethylacrylalkannin blocks downstream signaling by binding to the ATP pocket of FGFR1, and regulates the CDK1/Cdc25C pathway and ROS-JNK axis, thereby inducing G2/M phase arrest, necrosis and apoptosis in cancer cells, and inhibiting tumor proliferation. β,β-Dimethylacrylalkannin also acts as a colistin adjuvant to disrupt the cell membrane of Gram-negative bacteria. β,β-Dimethylacrylalkannin exhibits significant tumor-inhibitory effects with no obvious toxicity in PDX models, but chronic exposure to high doses may alter the relative lung/liver weights of rats, while acute exposure to high doses causes responses such as reduced motor activity. β,β-Dimethylacrylalkannin finds wide application in studies related to hepatocellular carcinoma, colorectal cancer, colistin-resistant bacterial infections, hepatitis and psoriasis .
    β,β-Dimethylacrylalkannin
  • HY-N5112AR
    β,β-Dimethylacrylalkannin (Standard)

    Arnebin 1 (Standard)

    		 Reference Standards HIF/HIF Prolyl-Hydroxylase Others
    β,β-Dimethylacrylalkannin (Standard) (Arnebin 1 (Standard)) is the analytical standard of β,β-Dimethylacrylalkannin (HY-N5112A). This product is intended for research and analytical applications. β,β-Dimethylacrylalkannin (Arnebin 1) is a napthoquinone isolated from Alkanna cappadocica , increases collagen and involucrin content in skin cells .
    β,β-Dimethylacrylalkannin (Standard)

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