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Targets Recommended:	5-HT Receptor 5 alpha Reductase FLAP CD73 RAR/RXR CXCR nAChR mGluR iGluR Protease-Activated Receptor (PAR) PPAR PIKfyve TGF-β Receptor Serotonin Transporter Oct3/4

Results for "5-HT1B Receptors Inhibitors" in MCE Product Catalog:

By Targets:	5-HT Receptor (5) Serotonin Transporter (3) Adrenergic Receptor (2)
By Research Areas:	Cardiovascular Disease (1) Neurological Disease (4)

5

Inhibitors & Agonists

1

Natural
Products

Cat. No.	Product Name	Target	Research Areas

Isamoltane hemifumarate	5-HT Receptor Adrenergic Receptor	Neurological Disease
Isamoltane hemifumarate is a selective antagonist of **5-HT_1B receptor, with an IC₅₀** of 39 nM for inhibits the binding of [¹²⁵I]ICYP to 5-HT_1B recognition sites in rat brain membranes. Isamoltane hemifumarate is also a β-adrenoceptor ligand, with an IC₅₀ of 8.4 nM. Isamoltane hemifumarate shows anxiolytic activity.

Vortioxetine Lu AA 21004	5-HT Receptor Serotonin Transporter	Neurological Disease
Vortioxetine is a inhibitor of *5-HT_1A, 5-HT_1B,* 5-HT_3A, 5-HT₇** receptor and SERT, with K_i values of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively.

Vortioxetine hydrobromide Lu AA21004 hydrobromide	5-HT Receptor Serotonin Transporter	Neurological Disease
Vortioxetine hydrobromide is a multimodal serotonergic agent, inhibits *5-HT_1A, 5-HT_1B,* 5-HT_3A, 5-HT₇** receptor and SERT with K_i values of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively.

Vortioxetine D8 Lu AA 21004 D8	5-HT Receptor Serotonin Transporter	Neurological Disease
Vortioxetine D8 is a deuterium labeled Vortioxetine. Vortioxetine is an inhibitor of *5-HT_1A, 5-HT_1B,* 5-HT_3A, 5-HT₇** receptor and SERT, with K_i values of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively.

Arotinolol	Adrenergic Receptor 5-HT Receptor	Cardiovascular Disease
Arotinolol is a nonselective α/β-adrenergic receptor blocker and a vasodilating β-blocker. Arotinolol also shows potency for inhibiting the binding of the radioligand ¹²⁵I-ICYP to *5HT_1B*-serotonergic receptor sites. Arotinolol is an antihypertensive agent for the treatment of a variety of cardiovascular pathologies as well as non-cardiovascular diseases.

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