LY393558
Based on 1 Customer Validation
LY393558 is a potent and orally active inhibitor of the 5-HT transporter and an antagonist of 5-HT1B and 5-HT1D receptors. LY393558 increase the extracellular levels of 5-HT in mice model frontal cortex. LY393558 can be used for researching depression.
For research use only. We do not sell to patients.
- Purity: 99.0%
- CAS No.: 271780-64-4
- Formula: C26H31FN4O4S2
- Molecular Weight:546.68
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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All 5-HT Receptor Isoforms
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Biological Activity
LY393558 (20 mg/kg; p.o., single) completely abolishes the reduction of levels of 5-HT induced by tetrodotoxin (1μM) in guinea pigs model[1].
LY393558 (1-20 mg/kg; p.o., single) significantly increases extracellular levels of 5-HT in rats model[1].
LY393558 (5 mg/kg/day; p.o., 21 days) can still elicit a further increase in extracellular 5-HT in chronic treatment[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female Dunkin Hartley guinea pigs (350-400 g)[1]
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Dosage:1-20 mg/kg
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Administration:p.o., single
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Result:Extracellular levels of 5-HT reached 200-250% at 1 mg/kg, while levels of 5-HT reached approximately 1500% at the highest dose 20 mg/kg.
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Animal Model:Female Dunkin Hartley guinea pigs (350-400 g)[1]
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Dosage:20 mg/kg
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Administration:p.o., single
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Result:Completely abolished the reduction of levels of 5-HT induced by tetrodotoxin (1μM).
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Animal Model:Male Lister Hooded rats (290-320 g)[1]
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Dosage:1-20 mg/kg
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Administration:p.o., single
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Result:Significantly increased extracellular levels of 5-HT.
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Animal Model:Male Lister Hooded rats (290-320 g)[1]
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Dosage:5 mg/kg/day
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Administration:p.o., 21 days
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Result:Still elicited a further increase in extracellular 5-HT in chronic treatment.
Chemical Information
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CAS No. 271780-64-4
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Appearance Solid
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Molecular Weight 546.68
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Formula C26H31FN4O4S2
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Color Light yellow to yellow
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SMILES
O=S(C1=CC=C(N(CCN2CC=C(C3=CNC4=C3C=CC(F)=C4)CC2)S(N(C(C)C)C5)(=O)=O)C5=C1)(C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 10 mg/mL (18.29 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8292 mL | 9.1461 mL | 18.2922 mL | 45.7306 mL |
| 5 mM | 0.3658 mL | 1.8292 mL | 3.6584 mL | 9.1461 mL | |
| 10 mM | 0.1829 mL | 0.9146 mL | 1.8292 mL | 4.5731 mL | |
| 15 mM | 0.1219 mL | 0.6097 mL | 1.2195 mL | 3.0487 mL |
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