1. GPCR/G Protein Neuronal Signaling
  2. 5-HT Receptor
  3. SB-216641A

SB-216641A  (Synonyms: SB-216641 hydrochloride)

Cat. No.: HY-103149
Handling Instructions

SB-216641A (SB-216641 hydrochloride) is a selective antagonist of 5-HT1B/D receptor. SB-216641A shows high affinity and selectivity for h5-HT1B receptors over h5-HT1D receptors. SB-216641A inhibits the function of SKF-99101H.

For research use only. We do not sell to patients.

SB-216641A Chemical Structure

SB-216641A Chemical Structure

CAS No. : 193611-67-5

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Description

SB-216641A (SB-216641 hydrochloride) is a selective antagonist of 5-HT1B/D receptor. SB-216641A shows high affinity and selectivity for h5-HT1B receptors over h5-HT1D receptors. SB-216641A inhibits the function of SKF-99101H[1][2].

IC50 & Target[1][2]

5-HT1B Receptor

 

5-HT1D Receptor

 

In Vivo

SB-216641A (0.6-20 mg/kg; i.p.; single dose) hinders the SKF-99101H induced hypothermia with dose-dependent manner in guinea pigs[1].
SB-216641A (559 nmol/kg; i.v.; single dose) improves the gastric relaxation observed after injection of 800 nmol/kg Sumatriptan (HY-B0121B) in dogs when combined with 5-HT1B/D receptor antagonist GR-127935[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Guinea pigs[1].
Dosage: 0.6, 2.0, 6.0 and 20.0 mg/kg.
Administration: Intraperitoneal injection; single dose.
Result: Significantly blocked the effects of SKF-99101H.
Animal Model: Dogs[2].
Dosage: 559 nmol/kg.
Administration: Intravenous injection; single dose.
Result: Improved the gastric relaxation.
Molecular Weight

523.02

Formula

C28H31ClN4O4

CAS No.
SMILES

O=C(C1=CC=C(C2=C(C)C=C(C3=NOC(C)=N3)C=C2)C=C1)NC4=CC=C(C(OCCN(C)C)=C4)OC.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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SB-216641A Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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SB-216641A
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HY-103149
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