193611-67-5
193611-67-5
Chemical Structure
SB-216641A
Synonym(s): SB-216641 hydrochloride
- CAS No.: 193611-67-5
- Formula:C28H31ClN4O4
- Molecular Weight:523.02
IUPAC Name: N-(3-(2-(dimethylamino)ethoxy)-4-methoxyphenyl)-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxamide hydrochloride
InChIKey: JPBMDMNORXKGHZ-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(C2=C(C)C=C(C3=NOC(C)=N3)C=C2)C=C1)NC4=CC=C(C(OCCN(C)C)=C4)OC.Cl
Biological Activity: SB-216641A (SB-216641 hydrochloride) is a selective antagonist of 5-HT1B/D receptor. SB-216641A shows high affinity and selectivity for h5-HT1B receptors over h5-HT1D receptors. SB-216641A inhibits the function of SKF-99101H[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SB-216641A | 98.04% | SB-216641A (SB-216641 hydrochloride) is a selective antagonist of 5-HT1B/D receptor. SB-216641A shows high affinity and selectivity for h5-HT1B receptors over h5-HT1D receptors. SB-216641A inhibits the function of SKF-99101H. | ||||||||||||||||||||
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References
- [1]. Hagan JJ, et al. Stimulation of 5-HT1B receptors causes hypothermia in the guinea pig. Eur J Pharmacol. 1997 Jul 23;331(2-3):169-74. [Content Brief]
- [2]. De Ponti F, et al. Role of 5-HT1B/D receptors in canine gastric accommodation: effect of sumatriptan and 5-HT1B/D receptor antagonists. Am J Physiol Gastrointest Liver Physiol. 2003 Jul;285(1):G96-104. [Content Brief]
