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Results for "

786-0

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Cytotoxin (1) Carbonic Anhydrase (1) HIF/HIF Prolyl-Hydroxylase (1) TAM Receptor (1) Topoisomerase (1)
By Research Areas:	Cancer (5)

6

Inhibitors & Agonists

1

Inhibitory Antibodies

1

Natural
Products

1

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Tilvestamab BGB149	TAM Receptor	Cancer
Tilvestamab (BGB149) is a humanized anti-AXL antibody that blocks AXL-mediated cell signaling. Tilvestamab significantly inhibits Gas6-induced AXL activation in 786-0-Luc RCC cells and inhibits downstream AKT phosphorylation. Tilvestamab can be used in cancer research, particularly in AXL overexpressing renal cell carcinomas .

Gly-7-MAD-MDCPT	ADC Cytotoxin Topoisomerase	Cancer
Gly-7-MAD-MDCPT (compound 4b) is an anticancer agent. Gly-7-MAD-MDCPT is a Camptothecin (HY-16560) compound, it shows cytotoxicity to various cancer cells with IC₅₀ values of 10-1000 nM .

hCAXII-IN-7	Carbonic Anhydrase	Others
hCAXII-IN-7 (compound 6e) is a hCA XII inhibitor. hCAXII-IN-7 has BBB permeability. hCAXII-IN-7 induces 786-0, SF-539 and HS 578 T cells apoptotic .

3,5-Dimethoxy-2,7-phenanthrenediol	Others	Cancer
3,5-Dimethoxy-2,7-phenanthrenediol (compound 2) is a phenanthrene compound isolated from the roots of Combretum laxum. 3,5-Dimethoxy-2,7-phenanthrenediol is cytotoxic to human cancer cell lines 786-0, MCF-7 and NCI/ADR-RES, with IC₅₀s of 73.26 μM, 118.40 μM and 83.99 μM respectively. 3,5-Dimethoxy-2,7-phenanthrenediol also has free radical scavenging activity with an IC₅₀ of 20.4 μM .

Pyrrolidine ricinoleamide	Others	Cancer
Pyrrolidine ricinoleamide ((R)-5d) is a fatty acid amide that exhibits effective antiproliferative activity against a series of cancer cells, including human glioma U251 cells. Pyrrolidine ricinoleamide can be used in cancer research .

HIF-1/2α-IN-1	HIF/HIF Prolyl-Hydroxylase	Cancer
HIF-1/2α-IN-1 is an orally active HIF-2α inhibitor. HIF-1/2α-IN-1 inhibits HIF-2α activity with an IC₅₀ value of 0.92 μM. HIF-1/2α-IN-1 also can decrease HIF-1α levels. HIF-1/2α-IN-1 can be used for the research of clear cell renal cell carcinoma (ccRCC) .

Cat. No.	Compare	Product Name	Species	Source

	Coagulation Factor X/F10 Protein, Human (HEK293, Fc) rHuCoagulation Factor X/F10, Fc; Coagulation factor X; Stuart factor; Stuart-Prower factor	Human	HEK293
	Factor X (F10) is a vitamin K-dependent glycoprotein that plays a key role in the blood coagulation process as factor Xa. Factor Xa, along with factor Va, calcium, and phospholipids, coordinates the conversion of prothrombin to thrombin, a key step in the coagulation cascade. Coagulation Factor X/F10 Protein, Human (HEK293, Fc) is the recombinant human-derived Coagulation Factor X/F10 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Coagulation Factor X/F10 Protein, Human (HEK293, Fc) is 457 a.a., with molecular weight of 80-130 & 25 kDa, respectively.

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