Cat. No.: HY-155271

hCAXII-IN-7

hCAXII-IN-7 (compound 6e) is a hCA XII inhibitor. hCAXII-IN-7 has BBB permeability. hCAXII-IN-7 induces 786-0, SF-539 and HS 578 T cells apoptotic.

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Formule: C₂₆H₂₅N₅O₆S₂
Masse moléculaire:567.64

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

hCAXII-IN-7 Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
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Help & FAQs
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Activité biologique

Description

hCAXII-IN-7 (compound 6e) is a hCA XII inhibitor. hCAXII-IN-7 has BBB permeability. hCAXII-IN-7 induces 786-0, SF-539 and HS 578 T cells apoptotic^[1].

Voir tous les produits spécifiques à Isoform Carbonic Anhydrase :

Cellular Effect

Cell Line	Type	Value	Description	References
786-0	GI₅₀	0.45 μM Compound: 6e	Growth inhibition of human 786-0 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human 786-0 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
A498	GI₅₀	>100 μM Compound: 6e	Growth inhibition of human A498 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human A498 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
A549	GI₅₀	>100 μM Compound: 6e	Growth inhibition of human A549 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human A549 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
ACHN	GI₅₀	>100 μM Compound: 6e	Growth inhibition of human ACHN cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human ACHN cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
BT-549	GI₅₀	1.42 μM Compound: 6e	Growth inhibition of human BT-549 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human BT-549 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
CAKI-1	GI₅₀	>100 μM Compound: 6e	Growth inhibition of human CAKI-1 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human CAKI-1 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
CCRF-CEM	GI₅₀	1.9 μM Compound: 6e	Growth inhibition of human CCRF-CEM cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human CCRF-CEM cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
COLO 205	GI₅₀	>100 μM Compound: 6e	Growth inhibition of human COLO 205 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human COLO 205 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
DU-145	GI₅₀	>100 μM Compound: 6e	Growth inhibition of human DU-145 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human DU-145 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
EKVX	GI₅₀	>100 μM Compound: 6e	Growth inhibition of human EKVX cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human EKVX cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
HCT-116	GI₅₀	33.1 μM Compound: 6e	Growth inhibition of human HCT-116 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human HCT-116 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
HCT-15	GI₅₀	>100 μM Compound: 6e	Growth inhibition of human HCT-15 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human HCT-15 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
HL-60(TB)	GI₅₀	2.28 μM Compound: 6e	Growth inhibition of human HL-60(TB) cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human HL-60(TB) cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
HOP-62	GI₅₀	>100 μM Compound: 6e	Growth inhibition of human HOP-62 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human HOP-62 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
HOP-92	GI₅₀	2.08 μM Compound: 6e	Growth inhibition of human HOP-92 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human HOP-92 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
Hs-578T	GI₅₀	1.18 μM Compound: 6e	Growth inhibition of human Hs-578T cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human Hs-578T cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
HT-29	GI₅₀	6.9 μM Compound: 6e	Growth inhibition of human HT-29 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human HT-29 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
IGROV-1	GI₅₀	>100 μM Compound: 6e	Growth inhibition of human IGROV-1 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human IGROV-1 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
K562	GI₅₀	2.74 μM Compound: 6e	Growth inhibition of human K562 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human K562 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
LOX IMVI	GI₅₀	3.27 μM Compound: 6e	Growth inhibition of human LOX IMVI cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human LOX IMVI cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
M14	GI₅₀	2.18 μM Compound: 6e	Growth inhibition of human M14 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human M14 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
Malme-3M	GI₅₀	2.72 μM Compound: 6e	Growth inhibition of human Malme-3M cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human Malme-3M cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
MCF7	GI₅₀	2.77 μM Compound: 6e	Growth inhibition of human MCF7 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human MCF7 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
MDA-MB-231	GI₅₀	6.16 μM Compound: 6e	Growth inhibition of human MDA-MB-231 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human MDA-MB-231 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
MDA-MB-435	GI₅₀	11.7 μM Compound: 6e	Growth inhibition of human MDA-MB-435 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human MDA-MB-435 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
MDA-MB-468	GI₅₀	>100 μM Compound: 6e	Growth inhibition of human MDA-MB-468 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human MDA-MB-468 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
MOLT-4	GI₅₀	2.19 μM Compound: 6e	Growth inhibition of human MOLT-4 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human MOLT-4 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
NCI/ADR-RES	GI₅₀	>100 μM Compound: 6e	Growth inhibition of human NCI/ADR-RES cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human NCI/ADR-RES cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
NCI-H23	GI₅₀	>100 μM Compound: 6e	Growth inhibition of human NCI-H23 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human NCI-H23 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
NCI-H322M	GI₅₀	>100 μM Compound: 6e	Growth inhibition of human NCI-H322M cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human NCI-H322M cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
NCI-H460	GI₅₀	>100 μM Compound: 6e	Growth inhibition of human NCI-H460 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human NCI-H460 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
NCI-H522	GI₅₀	>100 μM Compound: 6e	Growth inhibition of human NCI-H522 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human NCI-H522 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
OVCAR-3	GI₅₀	7.84 μM Compound: 6e	Growth inhibition of human OVCAR-3 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human OVCAR-3 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
OVCAR-4	GI₅₀	>100 μM Compound: 6e	Growth inhibition of human OVCAR-4 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human OVCAR-4 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
OVCAR-5	GI₅₀	>100 μM Compound: 6e	Growth inhibition of human OVCAR-5 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human OVCAR-5 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
OVCAR-8	GI₅₀	>100 μM Compound: 6e	Growth inhibition of human OVCAR-8 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human OVCAR-8 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
PC-3	GI₅₀	9.89 μM Compound: 6e	Growth inhibition of human PC-3 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human PC-3 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
RPMI-8226	GI₅₀	2 μM Compound: 6e	Growth inhibition of human RPMI-8226 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human RPMI-8226 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
RXF 393	GI₅₀	0.32 μM Compound: 6e	Growth inhibition of human RXF 393 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human RXF 393 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
SF-268	GI₅₀	9 μM Compound: 6e	Growth inhibition of human SF-268 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human SF-268 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
SF-295	GI₅₀	13 μM Compound: 6e	Growth inhibition of human SF-295 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human SF-295 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
SF-539	GI₅₀	0.89 μM Compound: 6e	Growth inhibition of human SF-539 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human SF-539 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
SK-MEL-2	GI₅₀	4.1 μM Compound: 6e	Growth inhibition of human SK-MEL-2 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human SK-MEL-2 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
SK-MEL-28	GI₅₀	4.88 μM Compound: 6e	Growth inhibition of human SK-MEL-28 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human SK-MEL-28 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
SK-MEL-5	GI₅₀	1.43 μM Compound: 6e	Growth inhibition of human SK-MEL-5 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human SK-MEL-5 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
SK-OV-3	GI₅₀	>100 μM Compound: 6e	Growth inhibition of human SK-OV-3 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human SK-OV-3 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
SN12C	GI₅₀	>100 μM Compound: 6e	Growth inhibition of human SN12C cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human SN12C cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
SNB-19	GI₅₀	7.92 μM Compound: 6e	Growth inhibition of human SNB-19 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human SNB-19 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
SNB-75	GI₅₀	2.83 μM Compound: 6e	Growth inhibition of human SNB-75 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human SNB-75 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
SR	GI₅₀	2.64 μM Compound: 6e	Growth inhibition of human SR cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human SR cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
SW-620	GI₅₀	>100 μM Compound: 6e	Growth inhibition of human SW620 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human SW620 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
TK-10	GI₅₀	>100 μM Compound: 6e	Growth inhibition of human TK-10 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human TK-10 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
U-251	GI₅₀	11.6 μM Compound: 6e	Growth inhibition of human U-251 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human U-251 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
UACC-257	GI₅₀	>100 μM Compound: 6e	Growth inhibition of human UACC-257 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human UACC-257 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
UACC-62	GI₅₀	4.18 μM Compound: 6e	Growth inhibition of human UACC-62 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human UACC-62 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
UO-31	GI₅₀	>100 μM Compound: 6e	Growth inhibition of human UO-31 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human UO-31 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]

Chemical Information

Masse moléculaire 567.64
Formule C₂₆H₂₅N₅O₆S₂
SMILES

O=S(C1=CC=C(N2C=C(/C=N/NC3=CC=C(C(OCC)=O)C=C3)C(C4=CC=C(S(=O)(C)=O)C=C4)=N2)C=C1)(N)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Ahmed RF, et al. Exploring novel anticancer pyrazole benzenesulfonamides featuring tail approach strategy as carbonic anhydrase inhibitors. Eur J Med Chem. 2023 Sep 19;261:115805. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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hCAXII-IN-7

Voir tous les produits spécifiques à Isoform Carbonic Anhydrase

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

hCAXII-IN-7 Related Classifications

HY-155271 Related Classifications