hCAXII-IN-7

Cat. No.: HY-155271: Data Sheet Handling Instructions
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hCAXII-IN-7 (compound 6e) is a hCA XII inhibitor. hCAXII-IN-7 has BBB permeability. hCAXII-IN-7 induces 786-0, SF-539 and HS 578 T cells apoptotic.

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hCAXII-IN-7 Chemical Structure

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CA CA I CA Ⅱ CA IX CA XII CA VII CA VI CA VA CA VB CA XIII CA XIV

Biological Activity
Purity & Documentation
References
Customer Review

Description

hCAXII-IN-7 (compound 6e) is a hCA XII inhibitor. hCAXII-IN-7 has BBB permeability. hCAXII-IN-7 induces 786-0, SF-539 and HS 578 T cells apoptotic^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
786-0	GI₅₀	0.45 μM Compound: 6e	Growth inhibition of human 786-0 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human 786-0 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
A498	GI₅₀	>100 μM Compound: 6e	Growth inhibition of human A498 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human A498 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
A549	GI₅₀	>100 μM Compound: 6e	Growth inhibition of human A549 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human A549 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
ACHN	GI₅₀	>100 μM Compound: 6e	Growth inhibition of human ACHN cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human ACHN cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
BT-549	GI₅₀	1.42 μM Compound: 6e	Growth inhibition of human BT-549 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human BT-549 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
CAKI-1	GI₅₀	>100 μM Compound: 6e	Growth inhibition of human CAKI-1 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human CAKI-1 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
CCRF-CEM	GI₅₀	1.9 μM Compound: 6e	Growth inhibition of human CCRF-CEM cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human CCRF-CEM cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
COLO 205	GI₅₀	>100 μM Compound: 6e	Growth inhibition of human COLO 205 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human COLO 205 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
DU-145	GI₅₀	>100 μM Compound: 6e	Growth inhibition of human DU-145 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human DU-145 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
EKVX	GI₅₀	>100 μM Compound: 6e	Growth inhibition of human EKVX cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human EKVX cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
HCT-116	GI₅₀	33.1 μM Compound: 6e	Growth inhibition of human HCT-116 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human HCT-116 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
HCT-15	GI₅₀	>100 μM Compound: 6e	Growth inhibition of human HCT-15 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human HCT-15 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
HL-60(TB)	GI₅₀	2.28 μM Compound: 6e	Growth inhibition of human HL-60(TB) cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human HL-60(TB) cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
HOP-62	GI₅₀	>100 μM Compound: 6e	Growth inhibition of human HOP-62 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human HOP-62 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
HOP-92	GI₅₀	2.08 μM Compound: 6e	Growth inhibition of human HOP-92 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human HOP-92 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
Hs-578T	GI₅₀	1.18 μM Compound: 6e	Growth inhibition of human Hs-578T cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human Hs-578T cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
HT-29	GI₅₀	6.9 μM Compound: 6e	Growth inhibition of human HT-29 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human HT-29 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
IGROV-1	GI₅₀	>100 μM Compound: 6e	Growth inhibition of human IGROV-1 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human IGROV-1 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
K562	GI₅₀	2.74 μM Compound: 6e	Growth inhibition of human K562 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human K562 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
LOX IMVI	GI₅₀	3.27 μM Compound: 6e	Growth inhibition of human LOX IMVI cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human LOX IMVI cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
M14	GI₅₀	2.18 μM Compound: 6e	Growth inhibition of human M14 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human M14 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
Malme-3M	GI₅₀	2.72 μM Compound: 6e	Growth inhibition of human Malme-3M cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human Malme-3M cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
MCF7	GI₅₀	2.77 μM Compound: 6e	Growth inhibition of human MCF7 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human MCF7 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
MDA-MB-231	GI₅₀	6.16 μM Compound: 6e	Growth inhibition of human MDA-MB-231 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human MDA-MB-231 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
MDA-MB-435	GI₅₀	11.7 μM Compound: 6e	Growth inhibition of human MDA-MB-435 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human MDA-MB-435 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
MDA-MB-468	GI₅₀	>100 μM Compound: 6e	Growth inhibition of human MDA-MB-468 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human MDA-MB-468 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
MOLT-4	GI₅₀	2.19 μM Compound: 6e	Growth inhibition of human MOLT-4 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human MOLT-4 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
NCI/ADR-RES	GI₅₀	>100 μM Compound: 6e	Growth inhibition of human NCI/ADR-RES cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human NCI/ADR-RES cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
NCI-H23	GI₅₀	>100 μM Compound: 6e	Growth inhibition of human NCI-H23 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human NCI-H23 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
NCI-H322M	GI₅₀	>100 μM Compound: 6e	Growth inhibition of human NCI-H322M cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human NCI-H322M cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
NCI-H460	GI₅₀	>100 μM Compound: 6e	Growth inhibition of human NCI-H460 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human NCI-H460 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
NCI-H522	GI₅₀	>100 μM Compound: 6e	Growth inhibition of human NCI-H522 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human NCI-H522 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
OVCAR-3	GI₅₀	7.84 μM Compound: 6e	Growth inhibition of human OVCAR-3 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human OVCAR-3 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
OVCAR-4	GI₅₀	>100 μM Compound: 6e	Growth inhibition of human OVCAR-4 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human OVCAR-4 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
OVCAR-5	GI₅₀	>100 μM Compound: 6e	Growth inhibition of human OVCAR-5 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human OVCAR-5 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
OVCAR-8	GI₅₀	>100 μM Compound: 6e	Growth inhibition of human OVCAR-8 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human OVCAR-8 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
PC-3	GI₅₀	9.89 μM Compound: 6e	Growth inhibition of human PC-3 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human PC-3 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
RPMI-8226	GI₅₀	2 μM Compound: 6e	Growth inhibition of human RPMI-8226 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human RPMI-8226 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
RXF 393	GI₅₀	0.32 μM Compound: 6e	Growth inhibition of human RXF 393 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human RXF 393 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
SF-268	GI₅₀	9 μM Compound: 6e	Growth inhibition of human SF-268 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human SF-268 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
SF-295	GI₅₀	13 μM Compound: 6e	Growth inhibition of human SF-295 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human SF-295 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
SF-539	GI₅₀	0.89 μM Compound: 6e	Growth inhibition of human SF-539 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human SF-539 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
SK-MEL-2	GI₅₀	4.1 μM Compound: 6e	Growth inhibition of human SK-MEL-2 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human SK-MEL-2 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
SK-MEL-28	GI₅₀	4.88 μM Compound: 6e	Growth inhibition of human SK-MEL-28 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human SK-MEL-28 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
SK-MEL-5	GI₅₀	1.43 μM Compound: 6e	Growth inhibition of human SK-MEL-5 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human SK-MEL-5 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
SK-OV-3	GI₅₀	>100 μM Compound: 6e	Growth inhibition of human SK-OV-3 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human SK-OV-3 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
SN12C	GI₅₀	>100 μM Compound: 6e	Growth inhibition of human SN12C cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human SN12C cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
SNB-19	GI₅₀	7.92 μM Compound: 6e	Growth inhibition of human SNB-19 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human SNB-19 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
SNB-75	GI₅₀	2.83 μM Compound: 6e	Growth inhibition of human SNB-75 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human SNB-75 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
SR	GI₅₀	2.64 μM Compound: 6e	Growth inhibition of human SR cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human SR cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
SW-620	GI₅₀	>100 μM Compound: 6e	Growth inhibition of human SW620 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human SW620 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
TK-10	GI₅₀	>100 μM Compound: 6e	Growth inhibition of human TK-10 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human TK-10 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
U-251	GI₅₀	11.6 μM Compound: 6e	Growth inhibition of human U-251 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human U-251 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
UACC-257	GI₅₀	>100 μM Compound: 6e	Growth inhibition of human UACC-257 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human UACC-257 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
UACC-62	GI₅₀	4.18 μM Compound: 6e	Growth inhibition of human UACC-62 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human UACC-62 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]
UO-31	GI₅₀	>100 μM Compound: 6e	Growth inhibition of human UO-31 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human UO-31 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 37748386]

Molecular Weight

567.64

Formula

C₂₆H₂₅N₅O₆S₂

SMILES

O=S(C1=CC=C(N2C=C(/C=N/NC3=CC=C(C(OCC)=O)C=C3)C(C4=CC=C(S(=O)(C)=O)C=C4)=N2)C=C1)(N)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ahmed RF, et al. Exploring novel anticancer pyrazole benzenesulfonamides featuring tail approach strategy as carbonic anhydrase inhibitors. Eur J Med Chem. 2023 Sep 19;261:115805. [Content Brief]

hCAXII-IN-7 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

hCAXII-IN-7Carbonic AnhydraseCarbonate dehydrataseBBB permeabilitycarbonic anhydraseInhibitorinhibitorinhibit

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hCAXII-IN-7

hCAXII-IN-7 Related Antibodies

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View All Carbonic Anhydrase Isoform Specific Products:

Biological Activity

Purity & Documentation

References

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hCAXII-IN-7 Related Classifications

Molarity Calculator

Dilution Calculator