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APA

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Cytotoxin (1) Aminopeptidase (2) Bacterial (2) COX (1) HSP (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (2) Infection (3)

7

Inhibitors & Agonists

3

Recombinant Proteins

1

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

6-Aminopenicillanic acid 6-APA	Bacterial	Infection
6-Aminopenicillanic acid (6-APA) is an important precursor for the synthesis of -lactam antibiotics. 6-Aminopenicillanic acid is the main product of Penicillin G (PenG) hydrolyzed by penicillin acylase (PA) .

HY-13950

S186

Others Others

S186 is a kind of sodium salts of calcium-acetylpropylamine phosphonate(APA); a new strontium-specific chelating agent.

Revaprazan hydrochloride	Bacterial COX	Infection
Revaprazan hydrochloride is a novel acid pump antagonist (APA). Revaprazan hydrochloride reduces COX-2 expression and has significant anti-inflammatory actions activities in H. pylori infection .

HY-145954

NAT2-IN-1

APA
Others Cancer

NAT2-IN-1 (APA) is an inhibitor of agent metabolic enzyme N-acetyltransferase 2 (NAT2). NAT2-IN-1 can selectively kill slow NAT2 cells .
HY-130997

17-GMB-APA-GA

ADC Cytotoxin HSP Infection Cancer

17-GMB-APA-GA is an ADC Cytotoxin. 17-GMB-APA-GA is a potent HSP90 inhibitor and used for latent T. gondii infection research .

EC33	Aminopeptidase	Cardiovascular Disease
EC33 is a selective aminopeptidase A (APA) inhibitor. EC33 blocks the pressor response of exogenous Ang II. EC33 does not cross the blood-brain barrier. EC33 has the potential for salt-dependent model of hypertension research .

Firibastat 1 Publications Verification QGC001; RB150	Aminopeptidase	Cardiovascular Disease
Firibastat (QGC001), an orally active brain penetrating proagent of EC33, is a first-in-class brain aminopeptidase A (APA) inhibitor (K_i=200 nM). Firibastat selectively and specifically inhibits conversion of brain angiotensin-II into angiotensin-III and decreases blood pressure in hypertensive rats .

Species:	Human (1) Mouse (1) Rat (1)
Tag:	His (3)
Source:	Sf9 insect cells (3)

Cat. No.	Compare	Product Name	Species	Source

	Aminopeptidase A Protein, Mouse (sf9, His) Glutamyl aminopeptidase; EAP; AP-A; CD249; ENPEP	Mouse	Sf9 insect cells
	The aminopeptidase A protein is a key player in the regulation of central hypertension, exerting its effects by selectively cleaving the N-terminal acidic residues of peptides such as angiotensin II. The enzyme's preference for specific substrates is regulated by calcium levels, underscoring its critical role in controlling blood pressure and maintaining cardiovascular health. Aminopeptidase A Protein, Mouse (sf9, His) is the recombinant mouse-derived Aminopeptidase A protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of Aminopeptidase A Protein, Mouse (sf9, His) is 905 a.a., with molecular weight of ~113 kDa.

	Aminopeptidase A Protein, Human (sf9, His) Glutamyl aminopeptidase; EAP; AP-A; CD249; ENPEP	Human	Sf9 insect cells
	Aminopeptidase A protein has calcium-regulating activity and plays a key role in central hypertension by preferentially cleaving N-terminal acidic residues, including angiotensin II. The specificity of this enzyme highlights its involvement in the regulation of blood pressure-related peptides, suggesting potential implications for the physiological mechanisms of hypertension. Aminopeptidase A Protein, Human (sf9, His) is the recombinant human-derived Aminopeptidase A protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of Aminopeptidase A Protein, Human (sf9, His) is 917 a.a., with molecular weight of ~115.5 kDa.

	Aminopeptidase A Protein, Rat (sf9, His) Glutamyl aminopeptidase; EAP; AP-A; CD249; ENPEP	Rat	Sf9 insect cells
	Aminopeptidase A, modulated by calcium, regulates central hypertension by preferentially cleaving N-terminal acidic residues from peptides, including angiotensin II. Aminopeptidase A Protein, Rat (sf9, His) is the recombinant rat-derived Aminopeptidase A protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of Aminopeptidase A Protein, Rat (sf9, His) is 905 a.a., with molecular weight of ~116 kDa.

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