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C53

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (3) Bcl-2 Family (1) MDM-2/p53 (8) Polo-like Kinase (PLK) (2) Small Interfering RNA (siRNA) (2)
By Research Areas:	Cancer (7)
Oligonucleotides:	Human Pre-designed siRNA Sets (2) siRNAs (2)

Inhibitors & Agonists

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-120373

MB710 1 Publications Verification	MDM-2/p53	Cancer
MB710, an aminobenzothiazole derivative, is a stabilizer of oncogenic p53 mutation Y220C. MB710 binds tightly to the Y220C pocket and stabilizes *p53-Y220C, with a K_d* of 4.1 μM. MB710 shows anticancer activity in p53-Y220C cell lines .

HY-153202

SLMP53-2	MDM-2/p53 Apoptosis	Cancer
SLMP53-2 is a mutant *p53* reactivator. SLMP53-2 restores wild-type-like conformation and DNA-binding ability of mutp53-Y220C by enhancing its interaction with the Hsp70, leading to the reestablishment of p53 transcriptional activity. SLMP53-2 can induce cell cycle arrest, apoptosis and endoplasmic reticulum (ER) stress. SLMP53-2 exhibits antitumor activity .

HY-179560

PMV6-PEG4-BI2536	Polo-like Kinase (PLK) MDM-2/p53	Cancer
PMV6-PEG4-BI2536 is a *p53-Y220C-PLK1* dual-functional compound, composed of a high-affinity *p53-Y220C* mutant binder (K_d ≈ 2.5 nM) and a potent PLK1 kinase inhibitor (IC₅₀ = 0.83 nM). PMV6-PEG4-BI2536 triggers TP53 ^Y220C cell G2/M arrest and apoptosis through PLK1 mislocalization and kinase inhibition, independent of p53 transcriptional reactivation. PMV6-PEG4-BI2536 can be used for the study of TP53 mutant cancers .

HY-RS10858

POLR3D Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
POLR3D Human Pre-designed siRNA Set A contains three designed siRNAs for POLR3D gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

POLR3D Human Pre-designed siRNA Set A POLR3D Human Pre-designed siRNA Set A

HY-RS02391

CDK5RAP3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CDK5RAP3 Human Pre-designed siRNA Set A contains three designed siRNAs for CDK5RAP3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CDK5RAP3 Human Pre-designed siRNA Set A CDK5RAP3 Human Pre-designed siRNA Set A

HY-100601

PK7242	MDM-2/p53
PK7242 is an inducer of reactivation of mutant p53 in cancer cells. In cancer cells carrying the Y220C mutant, PK7242 binds to the p53-Y220C core domain and induces growth inhibition, cell-cycle arrest, and apoptosis.

HY-179507

p53 Activator 17	MDM-2/p53 Apoptosis	Cancer
p53 Activator 17 is a *p53-Y220C* activator. p53 Activator 17 exhibits selective cytotoxicity and pro-apoptotic activity in p53-Y220C mutant cancer cell lines, with minimal effects in wild-type or p53-null cells. p53 Activator 17 induces a mutant-to-wild-type conformational shift in cellular p53-Y220C, accompanied by transcriptional activation of canonical p53 target genes, including BBC3 (PUMA) and MDM2. p53 Activator 17 can be used for the study of hepatocellular carcinoma and breast cancer .

HY-179506

p53 Activator 16	MDM-2/p53 Apoptosis	Cancer
P53 Activator 16 (Compound JC16) is a *p53* activator. P53 Activator 16 exhibits selective cytotoxicity and pro-apoptotic (apoptosis) activity towards p53-Y220C mutant cancer cells, while having little effect on wild-type or P53-deficient cells. P53 Activator 16 induces the conformational transition of cell p53-Y220C from the mutant form to the wild-type form, accompanied by the transcriptional activation of p53 target genes, without increasing the overall level of p53 protein. P53 Activator 16 can be used for the study of p53 mutant cancers .

HY-119408

MB725	MDM-2/p53 Bcl-2 Family	Cancer
MB725 is an ethylamide analogue of MB710 (HY-120373). MB725 increases mRNA levels of a range of *p53* target genes, notably *PUMA, p21, MDM2, NOXA* and *BAX. MB725 shows selective anticancer activity against p53-Y220C* cancer .

HY-181616

p53-Y220C/PLK1 modulator-1	MDM-2/p53 Polo-like Kinase (PLK)	Cancer
p53-Y220C/PLK1 modulator-1 (compound15) is a dual modulator targeting *p53-Y220C* and PLK1. p53-Y220C/PLK1 modulator-1 can be used in the cancer .

Host:	Rabbit (2)
Reactivity:	Human (2) Mouse (2)
Application:	IHC-P (2) IP (2) WB (2) FC (2)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (1) Recombinant (1)
Modification:	Unmodified (1)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P82183

	CDK5RAP3 Antibody (YA1928) C53; IC53; LZAP; HSF-27; MST016; PP1553; OK/SW-cl.114	WB, IHC-P, FC, IP	Human, Mouse
	CDK5RAP3 Antibody (YA1928) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CDK5RAP3.

HY-P82183A

	CDK5RAP3 Antibody (YA1928)(PBS only) C53; IC53; LZAP; HSF-27; MST016; PP1553; OK/SW-cl.114	WB, IHC-P, FC, IP	Human, Mouse
	CDK5RAP3 Antibody (YA1928) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CDK5RAP3.

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POLR3D Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
POLR3D Human Pre-designed siRNA Set A contains three designed siRNAs for POLR3D gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CDK5RAP3 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
CDK5RAP3 Human Pre-designed siRNA Set A contains three designed siRNAs for CDK5RAP3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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