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Cat. No.: HY-119408

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MB725

MB725 is an ethylamide analogue of MB710 (HY-120373). MB725 increases mRNA levels of a range of p53 target genes, notably PUMA, p21, MDM2, NOXA and BAX. MB725 shows selective anticancer activity against p53-Y220C cancer.

For research use only. We do not sell to patients.

CAS No.: 2230058-99-6
Formula: C₁₈H₂₁IN₄O₂S
Molecular Weight:484.36

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (284 KB)

MB725 Chemical Structure

CAS No.: 2230058-99-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

Bax

All Bcl-2 Family Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
BXPC-3	IC₅₀	18 μM Compound: MB725; 72	Antiproliferative activity against human BxPC3 cells harboring p53 Y220C mutant after 72 hrs by CellTiter-Glo assay Antiproliferative activity against human BxPC3 cells harboring p53 Y220C mutant after 72 hrs by CellTiter-Glo assay	[PMID: 29702446]
Huh-7	IC₅₀	10 μM Compound: MB725; 72	Antiproliferative activity against human HuH7 cells harboring p53 Y220C mutant after 72 hrs by CellTiter-Glo assay Antiproliferative activity against human HuH7 cells harboring p53 Y220C mutant after 72 hrs by CellTiter-Glo assay	[PMID: 29702446]
NUGC-3	IC₅₀	10 μM Compound: MB725; 72	Antiproliferative activity against human NUGC3 cells harboring p53 Y220C mutant after 72 hrs by CellTiter-Glo assay Antiproliferative activity against human NUGC3 cells harboring p53 Y220C mutant after 72 hrs by CellTiter-Glo assay	[PMID: 29702446]
NUGC-4	IC₅₀	>120 μM Compound: MB725; 72	Antiproliferative activity against human NUGC4 cells harboring wild-type p53 after 72 hrs by CellTiter-Glo assay Antiproliferative activity against human NUGC4 cells harboring wild-type p53 after 72 hrs by CellTiter-Glo assay	[PMID: 29702446]
SW1088	IC₅₀	>120 μM Compound: MB725; 72	Antiproliferative activity against human SW1088 cells harboring p53 Y220C mutant after 72 hrs by CellTiter-Glo assay Antiproliferative activity against human SW1088 cells harboring p53 Y220C mutant after 72 hrs by CellTiter-Glo assay	[PMID: 29702446]
WI-38	IC₅₀	>120 μM Compound: MB725; 72	Antiproliferative activity against human WI38 cells after 72 hrs by CellTiter-Glo assay Antiproliferative activity against human WI38 cells after 72 hrs by CellTiter-Glo assay	[PMID: 29702446]

Chemical Information

CAS No. 2230058-99-6
Molecular Weight 484.36
Formula C₁₈H₂₁IN₄O₂S
SMILES

O=C(NCC)C=1C(O)=C(I)C(=C2SC(=NC21)N(CC)CC)N3C=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (284 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Baud MGJ, et al. Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines. Eur J Med Chem. 2018 May 25;152:101-114. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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