1. Apoptosis
  2. MDM-2/p53
  3. MB710

MB710 

Cat. No.: HY-120373
Handling Instructions

MB710, an aminobenzothiazole derivative, is a stabilizer of oncogenic p53 mutation Y220C. MB710 binds tightly to the Y220C pocket and stabilizes p53-Y220C, with a Kd of 4.1 μM. MB710 shows anticancer activity in p53-Y220C cell lines.

For research use only. We do not sell to patients.

MB710 Chemical Structure

MB710 Chemical Structure

CAS No. : 2230044-57-0

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5 mg USD 600 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1050 In-stock
Estimated Time of Arrival: December 31
25 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
50 mg USD 3600 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

MB710, an aminobenzothiazole derivative, is a stabilizer of oncogenic p53 mutation Y220C. MB710 binds tightly to the Y220C pocket and stabilizes p53-Y220C, with a Kd of 4.1 μM. MB710 shows anticancer activity in p53-Y220C cell lines[1].

IC50 & Target

Kd: 4 μM (p53-Y220C)

In Vitro

MB710 (0-200 μM; 72 hours) shows relatively low toxicity against all cell lines tested at concentrations up to 60 μM, while showing initial selective viability reduction at higher concentrations[1].
MB710 (72 hours) treats cancer cell lines NUGC3, NUGC4, WI38 and SW1088, with IC50s of 90, 120, >120, >120 μM, respectively[1].
MB710 (0-120 μM; 72 hours; HUH-7 cells) shows stronger cytotoxic effects in presence of p53-Y220C[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: NUGC3 (mutant p53 Y220C), HUH-7 (mutant p53 Y220C), NUGC4 (p53 WT), HUH-6 cells (p53 WT)
Concentration: 0-200 μM
Incubation Time: 72 hours
Result: Showed relatively low toxicity against all cell lines tested at concentrations up to 60 μM. NUGC3 was the most sensitive cell line.
Molecular Weight

457.29

Formula

C₁₆H₁₆IN₃O₃S

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
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MB710
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