2230058-99-6
2230058-99-6
Chemical Structure
MB725
- CAS No.: 2230058-99-6
- Formula:C18H21IN4O2S
- Molecular Weight:484.36
IUPAC Name: 2-(diethylamino)-N-ethyl-5-hydroxy-6-iodo-7-(1H-pyrrol-1-yl)benzo[d]thiazole-4-carboxamide
InChIKey: GBNAUQMZRRFQTA-UHFFFAOYSA-N
SMILES: O=C(NCC)C=1C(O)=C(I)C(=C2SC(=NC21)N(CC)CC)N3C=CC=C3
Biological Activity: MB725 is an ethylamide analogue of MB710 (HY-120373). MB725 increases mRNA levels of a range of p53 target genes, notably PUMA, p21, MDM2, NOXA and BAX. MB725 shows selective anticancer activity against p53-Y220C cancer[1].
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MB725 | MB725 is an ethylamide analogue of MB710 (HY-120373). MB725 increases mRNA levels of a range of p53 target genes, notably PUMA, p21, MDM2, NOXA and BAX. MB725 shows selective anticancer activity against p53-Y220C cancer. | |||||||||||||||||||||
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