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E3 ligase Ligand-Linker Conjugates 32

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製品番号 製品名 Target 研究分野 構造式
  • HY-126458
    Thalidomide-O-PEG2-propargyl

    E3 ligase Ligand-Linker Conjugates 32

    		 E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis Cancer
    Thalidomide-O-PEG2-propargyl (E3 ligase Ligand-Linker Conjugates 32) is an E3 ligase ligand-linker conjugate. Thalidomide-O-PEG2-propargyl is also a click chemistry reagent containing an alkyne group, which can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAC) with molecules bearing an azide group .
    Thalidomide-O-PEG2-propargyl
  • HY-115446A
    Lenalidomide-C4-NH2 hydrochloride

    Cereblon Ligand 1 hydrochloride; E3 ligase Ligand-Linker Conjugates 32 hydrochloride

    		 E3 Ligase Ligand-Linker Conjugates Cancer
    Lenalidomide-C4-NH2 hydrochloride is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C4-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC (Compound 24), which has IC50s of 0.98 nM and 13.7 nM in inhibition of RS4;11 and MOLM-13 acute leukemia cell lines growth, respectively .
    Lenalidomide-C4-NH2 hydrochloride
  • HY-157590
    E3 ligase Ligand-Linker Conjugate 32

    		E3 Ligase Ligand-Linker Conjugates Cancer
    E3 ligase Ligand-Linker Conjugate 32 is a conjugate of E3 ligase ligand and linker, consisting of (S,R,S)-AHPC (HY-125845) and the corresponding Linker. (S,R,S)-AHPC is a VH032-based von Hippel-Lindau (VHL) ligand that recruits VHL proteins. E3 ligase Ligand-Linker Conjugate 32 can be used as a key intermediate for the synthesis of complete PROTAC molecules.
    E3 ligase Ligand-Linker Conjugate 32

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