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GPC3

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15

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Cat. No. Compare Product Name Species Source
  • HY-P78674
    Glypican-3/GPC3 Protein, Human (S359F, HEK293, His)

    GPC3; OCI5; Glypican-3; GTR2-2; MXR7; DGSX; SDYS ; SGB; SGBS; SGBS1

    		 Human HEK293
    Glypican-3 (GPC3) Protein, a cell surface proteoglycan, orchestrates intricate regulatory roles in key signaling pathways crucial for developmental processes. Through its GPI-anchor, GPC3 negatively modulates the hedgehog signaling pathway by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins, leading to complex internalization and subsequent lysosomal degradation. Simultaneously, it exerts positive regulation on both canonical and non-canonical Wnt signaling pathways by binding to the Wnt receptor Frizzled, enhancing the interaction between Frizzled and Wnt ligands. GPC3 binds to CD81, reducing the availability of free CD81 for binding to the transcriptional repressor HHEX, resulting in nuclear translocation of HHEX and transcriptional repression. Additionally, GPC3 inhibits the dipeptidyl peptidase activity of DPP4. Functionally, GPC3 plays pivotal roles in limb patterning, skeletal development, renal branching morphogenesis, and coronary vascular development. It also modulates the effects of growth factors BMP2, BMP7, and FGF7 on renal branching morphogenesis and contributes to the regulation of cell movements during gastrulation. GPC3 exists as a heterodimer formed by disulfide linkage and interacts with various molecules, including DPP4, FGF2, WNT5A, WNT3A, WNT7B, hedgehog proteins SHH and IHH, and Wnt receptors FZD4, FZD7, and FZD8, showcasing its pivotal role in coordinating developmental processes. Glypican-3/GPC3 Protein, Human (S359F, HEK293, His) is the recombinant human-derived Glypican-3/GPC3 protein, expressed by HEK293 , with C-His labeled tag and S359F mutation. The total length of Glypican-3/GPC3 Protein, Human (S359F, HEK293, His) is 535 a.a., with molecular weight of 68-120 kDa.
  • HY-P701293
    PE-labeled Glypican-3/GPC3 Protein, Human (HEK293, His)

    GPC3; OCI5; Glypican-3; GTR2-2; MXR7; DGSX; SDYS ; SGB; SGBS; SGBS1

    		 Human HEK293
    The Glypican-3 (GPC3) protein is a cell surface proteoglycan that plays complex regulatory roles in key signaling pathways critical to developmental processes. Through its GPI anchoring, GPC3 negatively regulates the Hedgehog signaling pathway by competing with the Hedgehog receptor PTC1 for binding to Hedgehog protein, leading to complex internalization and subsequent lysosomal degradation. PE-labeled Glypican-3/GPC3 Protein, Human (HEK293, His) is the recombinant human-derived PE-labeled Glypican-3/GPC3 protein, expressed by HEK293 , with His labeled tag. The total length of PE-labeled Glypican-3/GPC3 Protein, Human (HEK293, His) is 535 a.a., with molecular weight of 64.5 kDa.
  • HY-P78304
    Glypican-3/GPC3 Protein, Cynomolgus (HEK293, His)

    GPC3; DGSX; Glypican 3; GTR2-2; MXR7; OCI5; OCI-5; SGB; SGBS; SGBS1SDYS; SDYS; SGBS1

    		 Cynomolgus HEK293
    GPC3 is a member of the heparan sulfate proteoglycans (HSPGs), and attaches to the cell surface by a glycosylphosphatidylinositol anchor. GPC3 is overexpressed in hepatocellular carcinoma (HCC) and can be used as a tumor marker for HCC. Membrane GPC3 can interact with several growth factors to promote the binding of growth factors to their receptors. GPC3 can form a complex with Wnt and activates Wnt signaling, leading to the HCC growth. In addition, GPC3 is also involved in the pathogenesis of Simpson-Golabi-Behmel overgrowth syndrome, regulates cell growth, regulates embryonic and fetal development. Glypican-3/GPC3 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Glypican-3/GPC3 protein, expressed by HEK293 , with C-His labeled tag. The total length of Glypican-3/GPC3 Protein, Cynomolgus (HEK293, His) is 535 a.a., with molecular weight of ~42 kDa & 70-135 kDa, respectively.
  • HY-P701292
    FITC-labeled Glypican-3/GPC3 Protein, Human (HEK293, His)

    GPC3; OCI5; Glypican-3; GTR2-2; MXR7; DGSX; SDYS ; SGB; SGBS; SGBS1

    		 Human HEK293
    The Glypican-3 (GPC3) protein is a cell surface proteoglycan that plays complex regulatory roles in key signaling pathways critical to developmental processes. Through its GPI anchoring, GPC3 negatively regulates the Hedgehog signaling pathway by competing with the Hedgehog receptor PTC1 for binding to Hedgehog protein, leading to complex internalization and subsequent lysosomal degradation. FITC-labeled Glypican-3/GPC3 Protein, Human (HEK293, His) is the recombinant human-derived FITC-labeled Glypican-3/GPC3 protein, expressed by HEK293 , with His labeled tag. The total length of FITC-labeled Glypican-3/GPC3 Protein, Human (HEK293, His) is 535 a.a., with molecular weight of 40 kDa & 32 kDa & 66-115 kDa, respectively.
  • HY-P701291
    FITC-Labeled Glypican 3/GPC3 Protein, Human (HEK293, Fc)

    GPC3; OCI5; Glypican-3; GTR2-2; MXR7; DGSX; SDYS ; SGB; SGBS; SGBS1

    		 Human HEK293
    The Glypican-3 (GPC3) protein is a cell surface proteoglycan that plays complex regulatory roles in key signaling pathways critical to developmental processes. Through its GPI anchoring, GPC3 negatively regulates the Hedgehog signaling pathway by competing with the Hedgehog receptor PTC1 for binding to Hedgehog protein, leading to complex internalization and subsequent lysosomal degradation. FITC-Labeled Glypican 3/GPC3 Protein, Human (HEK293, Fc) is the recombinant human-derived FITC-Labeled Glypican 3/GPC3 protein, expressed by HEK293 , with Fc labeled tag. The total length of FITC-Labeled Glypican 3/GPC3 Protein, Human (HEK293, Fc) is 535 a.a., with molecular weight of 40 kDa & 60 kDa & 87-120 kDa, respectively.
  • HY-P72373
    Glypican-3/GPC3 Protein, Human (Biotinylated, HEK293, His-Avi)

    Glypican-3; GTR2-2; Intestinal protein OCI-5; MXR7; GPC3; OCI5

    		 Human HEK293
    The Glypican-3 (GPC3) protein is a cell surface proteoglycan that plays complex regulatory roles in key signaling pathways critical to developmental processes. Through its GPI anchoring, GPC3 negatively regulates the Hedgehog signaling pathway by competing with the Hedgehog receptor PTC1 for binding to Hedgehog protein, leading to complex internalization and subsequent lysosomal degradation. Glypican-3/GPC3 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived Glypican-3/GPC3 protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag. The total length of Glypican-3/GPC3 Protein, Human (Biotinylated, HEK293, His-Avi) is 535 a.a., with molecular weight of 70-130 & 40 kDa, respectively.
  • HY-P700414
    Glypican-3/GPC3 Protein, Human (HEK293, His-Myc)

    Glypican-3; GTR2-2; Intestinal protein OCI-5; MXR7; GPC3; OCI5

    		 Human HEK293
    Glypican-3 (GPC3) Protein, a cell surface proteoglycan, orchestrates intricate regulatory roles in key signaling pathways crucial for developmental processes. Through its GPI-anchor, GPC3 negatively modulates the hedgehog signaling pathway by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins, leading to complex internalization and subsequent lysosomal degradation. Simultaneously, it exerts positive regulation on both canonical and non-canonical Wnt signaling pathways by binding to the Wnt receptor Frizzled, enhancing the interaction between Frizzled and Wnt ligands. GPC3 binds to CD81, reducing the availability of free CD81 for binding to the transcriptional repressor HHEX, resulting in nuclear translocation of HHEX and transcriptional repression. Additionally, GPC3 inhibits the dipeptidyl peptidase activity of DPP4. Functionally, GPC3 plays pivotal roles in limb patterning, skeletal development, renal branching morphogenesis, and coronary vascular development. It also modulates the effects of growth factors BMP2, BMP7, and FGF7 on renal branching morphogenesis and contributes to the regulation of cell movements during gastrulation. GPC3 exists as a heterodimer formed by disulfide linkage and interacts with various molecules, including DPP4, FGF2, WNT5A, WNT3A, WNT7B, hedgehog proteins SHH and IHH, and Wnt receptors FZD4, FZD7, and FZD8, showcasing its pivotal role in coordinating developmental processes. Glypican-3/GPC3 Protein, Human (HEK293, His-Myc) is the recombinant human-derived Glypican-3/GPC3 protein, expressed by HEK293 , with N-Myc, N-6*His labeled tag and G537R mutation. The total length of Glypican-3/GPC3 Protein, Human (HEK293, His-Myc) is 535 a.a., with molecular weight of 65 kDa.
  • HY-P70487G
    GMP Glypican-3/GPC3 Protein, Human (HEK293, His)

    Glypican-3; GTR2-2; Intestinal protein OCI-5; MXR7; GPC3; OCI5

    		 Human HEK293
    The Glypican-3 (GPC3) protein is a cell surface proteoglycan that plays complex regulatory roles in key signaling pathways critical to developmental processes. Through its GPI anchoring, GPC3 negatively regulates the Hedgehog signaling pathway by competing with the Hedgehog receptor PTC1 for binding to Hedgehog protein, leading to complex internalization and subsequent lysosomal degradation. GMP Glypican-3/GPC3 Protein, Human (HEK293, His) is the recombinant human-derived Glypican-3/GPC3 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of GMP Glypican-3/GPC3 Protein, Human (HEK293, His) is 535 a.a., with molecular weight of 70-150 & 38 kDa, respectively.
  • HY-P77548
    Glypican-3/GPC3 Protein, Human (Biotinylated, HEK293, His)

    Glypican-3; GTR2-2; Intestinal protein OCI-5; MXR7; GPC3; OCI5

    		 Human HEK293
    The Glypican-3 (GPC3) protein is a cell surface proteoglycan that plays complex regulatory roles in key signaling pathways critical to developmental processes. Through its GPI anchoring, GPC3 negatively regulates the Hedgehog signaling pathway by competing with the Hedgehog receptor PTC1 for binding to Hedgehog protein, leading to complex internalization and subsequent lysosomal degradation. Glypican-3/GPC3 Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived Glypican-3/GPC3 protein, expressed by HEK293 , with C-His labeled tag. The total length of Glypican-3/GPC3 Protein, Human (Biotinylated, HEK293, His) is 559 a.a., with molecular weight of ~62.2 KDa.
  • HY-P72628
    Glypican-3/GPC3 Protein, Rhesus Macaque (HEK293, His)

    Glypican-3; GTR2-2; Intestinal protein OCI-5; MXR7; GPC3; OCI5

    		 Rhesus Macaque HEK293
    GPC3 is a member of the heparan sulfate proteoglycans (HSPGs), and attaches to the cell surface by a glycosylphosphatidylinositol anchor. GPC3 is overexpressed in hepatocellular carcinoma (HCC) and can be used as a tumor marker for HCC. Membrane GPC3 can interact with several growth factors to promote the binding of growth factors to their receptors. GPC3 can form a complex with Wnt and activates Wnt signaling, leading to the HCC growth. In addition, GPC3 is also involved in the pathogenesis of Simpson-Golabi-Behmel overgrowth syndrome, regulates cell growth, regulates embryonic and fetal development. Glypican-3/GPC3 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived Glypican-3/GPC3 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Glypican-3/GPC3 Protein, Rhesus Macaque (HEK293, His) is 535 a.a., with molecular weight of 38 & 65-120 kDa, respectively.
  • HY-P74122
    Glypican-3/GPC3 Protein, Human (S495A, HEK293, Fc)

    Glypican-3; GTR2-2; Intestinal protein OCI-5; MXR7; GPC3; OCI5

    		 Human HEK293
    The Glypican-3 (GPC3) protein is a cell surface proteoglycan that plays complex regulatory roles in key signaling pathways critical to developmental processes. Through its GPI anchoring, GPC3 negatively regulates the Hedgehog signaling pathway by competing with the Hedgehog receptor PTC1 for binding to Hedgehog protein, leading to complex internalization and subsequent lysosomal degradation. Glypican-3/GPC3 Protein, Human (S495A, HEK293, Fc) is the recombinant human-derived Glypican-3/GPC3 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of Glypican-3/GPC3 Protein, Human (S495A, HEK293, Fc) is 550 a.a., with molecular weight of ~86.11 kDa.
  • HY-P70367
    Glypican-3/GPC3 Protein, Human (HEK293, Fc)

    rHuGlypican-3/GPC3, Fc; Glypican-3; GTR2-2; Intestinal protein OCI-5; MXR7; GPC3; OCI5

    		 Human HEK293
    The Glypican-3 (GPC3) protein is a cell surface proteoglycan that plays complex regulatory roles in key signaling pathways critical to developmental processes. Through its GPI anchoring, GPC3 negatively regulates the Hedgehog signaling pathway by competing with the Hedgehog receptor PTC1 for binding to Hedgehog protein, leading to complex internalization and subsequent lysosomal degradation. Glypican-3/GPC3 Protein, Human (HEK293, Fc) is the recombinant human-derived Glypican-3/GPC3 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Glypican-3/GPC3 Protein, Human (HEK293, Fc) is 535 a.a., with molecular weight of 100-120 & 65 & 40 kDa, respectively.
  • HY-P73078
    Glypican-3/GPC3 Protein, Mouse (sf9, His)

    Glypican-3; GTR2-2; Intestinal protein OCI-5; MXR7; GPC3; OCI5

    		 Mouse Sf9 insect cells
    GPC3 is a cell surface proteoglycan that regulates Hedgehog and Wnt signaling. Glypican-3/GPC3 Protein, Mouse (sf9, His) is the recombinant mouse-derived Glypican-3/GPC3 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of Glypican-3/GPC3 Protein, Mouse (sf9, His) is 558 a.a., with molecular weight of ~62 kDa.
  • HY-P70872
    Glypican-3/GPC3 Protein, Mouse (HEK293, His)

    Glypican-3; GTR2-2; Intestinal protein OCI-5; MXR7; GPC3; OCI5

    		 Mouse HEK293
    GPC3 is a cell surface proteoglycan that regulates Hedgehog and Wnt signaling. Glypican-3/GPC3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Glypican-3/GPC3 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Glypican-3/GPC3 Protein, Mouse (HEK293, His) is 533 a.a., with molecular weight of 40 & 72-150 kDa, respectively.
  • HY-P70487
    Glypican-3/GPC3 Protein, Human (HEK293, His)

    Glypican-3; GTR2-2; Intestinal protein OCI-5; MXR7; GPC3; OCI5

    		 Human HEK293
    The Glypican-3 (GPC3) protein is a cell surface proteoglycan that plays complex regulatory roles in key signaling pathways critical to developmental processes. Through its GPI anchoring, GPC3 negatively regulates the Hedgehog signaling pathway by competing with the Hedgehog receptor PTC1 for binding to Hedgehog protein, leading to complex internalization and subsequent lysosomal degradation. Glypican-3/GPC3 Protein, Human (HEK293, His) is the recombinant human-derived Glypican-3/GPC3 protein, expressed by HEK293 , with C-His labeled tag.

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