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Gymnema

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By Targets:	Antibiotic (2) Apoptosis (1) Autophagy (1) LXR (1) mTOR (1) Reference Standards (1) Taste Receptor (1)
By Research Areas:	Infection (2) Metabolic Disease (6)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N2268

Gymnemagenin	Antibiotic	Infection Metabolic Disease
Gymnemagenin is a triterpenoid isolated from G. sylvestre. Gymnemagenin is an agent for diabetes and obesity and also possesses antiviral properties .

HY-N2541

Gymnemic acid I	Taste Receptor mTOR Autophagy Apoptosis	Metabolic Disease
Gymnemic acid I is a bioactive triterpene saponin found in Gymnema sylvestre. Gymnemic acid I is an antisweetness inhibitor via human sweet receptor type 1 receptor 2 (T1R2) and T1R3. Gymnemic acid I is a ribosomal protein biosynthesis inhibitor. Gymnemic acid I has antidiabetic effects. Gymnema acid I induces autophagy-protected MIN-6 cells from apoptosis under high glucose stress by inhibiting the phosphorylation activity of mTOR .

HY-N2273

Gymnestrogenin	LXR	Metabolic Disease
Gymnestrogenin is a pentahydroxytriterpene from the leaves of Gymnema sylvestre R.Br . Gymnestrogenin is a LXR antagonist with IC₅₀s of 2.5 and 1.4 μM for LXRα and LXRβ transactivation, respectively. Gymnestrogenin reduces the transcriptional activity of LXR even on its own promoter, thus reducing the mRNA expression .

HY-N3613

Conduritol A	Others	Metabolic Disease
Conduritol A is a hypoglycemic agent which inhibits the absorption of glucose and can be extracted from Gymnema sylvestre .

HY-N12459

Gymnemanol	Others	Others
Gymnemanol is a triterpene isolated from Gymnema sylvestre (Gymnema sylvestre).

HY-N2275

21-O-Tigloylgymnemagenin	Others	Others
21-O-Tigloylgymnemagenin (Compound 7) is a acylated triterpenes isolated from Gymnema sylvestre .

HY-N2268R

Gymnemagenin (Standard)	Antibiotic Reference Standards	Infection Metabolic Disease
Gymnemagenin (Standard) is the analytical standard of Gymnemagenin. This product is intended for research and analytical applications. Gymnemagenin is a triterpenoid isolated from G. sylvestre. Gymnemagenin is an agent for diabetes and obesity and also possesses antiviral properties .

HY-N18688

Gymnema sylvestre extract	Others	Metabolic Disease
Gymnema sylvestre extract, derived from the leaves of the Gymnema sylvestre plant, is renowned for its anti-diabetic and blood sugar-regulating properties. The key active compounds in the extract are gymnemic acids, which are responsible for its ability to block the taste of sweetness and reduce sugar absorption in the intestines.

Gymnemagenin	Triterpenes Classification of Application Fields Terpenoids Asclepiadaceae Metabolic Disease Plants Disease Research Fields Gymnema sylvestre (Retz.) Schult. Source Classification	Antibiotic
Gymnemagenin is a triterpenoid isolated from G. sylvestre. Gymnemagenin is an agent for diabetes and obesity and also possesses antiviral properties .

Gymnemic acid I	Triterpenes Classification of Application Fields Terpenoids Asclepiadaceae Metabolic Disease Plants Disease Research Fields Gymnema sylvestre (Retz.) Schult. Source Classification	Taste Receptor mTOR Autophagy Apoptosis
Gymnemic acid I is a bioactive triterpene saponin found in Gymnema sylvestre. Gymnemic acid I is an antisweetness inhibitor via human sweet receptor type 1 receptor 2 (T1R2) and T1R3. Gymnemic acid I is a ribosomal protein biosynthesis inhibitor. Gymnemic acid I has antidiabetic effects. Gymnema acid I induces autophagy-protected MIN-6 cells from apoptosis under high glucose stress by inhibiting the phosphorylation activity of mTOR .

Gymnestrogenin	Triterpenes Classification of Application Fields Terpenoids Asclepiadaceae Metabolic Disease Plants Disease Research Fields Gymnema sylvestre (Retz.) Schult. Source Classification	LXR
Gymnestrogenin is a pentahydroxytriterpene from the leaves of Gymnema sylvestre R.Br . Gymnestrogenin is a LXR antagonist with IC₅₀s of 2.5 and 1.4 μM for LXRα and LXRβ transactivation, respectively. Gymnestrogenin reduces the transcriptional activity of LXR even on its own promoter, thus reducing the mRNA expression .

Conduritol A	Natural Products Asclepiadaceae Plants Gymnema sylvestre (Retz.) Schult. Source Classification	Others
Conduritol A is a hypoglycemic agent which inhibits the absorption of glucose and can be extracted from Gymnema sylvestre .

Gymnemanol	Triterpenes Terpenoids Asclepiadaceae Plants Gymnema sylvestre (Retz.) Schult. Source Classification	Others
Gymnemanol is a triterpene isolated from Gymnema sylvestre (Gymnema sylvestre).

21-O-Tigloylgymnemagenin	Triterpenes Classification of Application Fields Terpenoids Asclepiadaceae Other Diseases Plants Disease Research Fields Gymnema sylvestre (Retz.) Schult. Source Classification	Others
21-O-Tigloylgymnemagenin (Compound 7) is a acylated triterpenes isolated from Gymnema sylvestre .

Gymnemagenin (Standard)	Triterpenes Terpenoids Asclepiadaceae Plants Gymnema sylvestre (Retz.) Schult. Source Classification	Antibiotic Reference Standards
Gymnemagenin (Standard) is the analytical standard of Gymnemagenin. This product is intended for research and analytical applications. Gymnemagenin is a triterpenoid isolated from G. sylvestre. Gymnemagenin is an agent for diabetes and obesity and also possesses antiviral properties .

Gymnema sylvestre extract	Structural Classification Extract	Others
Gymnema sylvestre extract, derived from the leaves of the Gymnema sylvestre plant, is renowned for its anti-diabetic and blood sugar-regulating properties. The key active compounds in the extract are gymnemic acids, which are responsible for its ability to block the taste of sweetness and reduce sugar absorption in the intestines.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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Gymnema

Inhibitors & Agonists

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Natural
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