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Results for "

Ku70

" in MedChemExpress (MCE) Product Catalog:

6

Inhibitors & Agonists

2

Recombinant Proteins

3

Antibodies

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  • HY-P73846
    Ku70-Ku80 Heterodimer Protein, Human (sf9, His)

    XRCC5-XRCC6 Heterodimer Protein; X-ray repair cross-complementing protein

    		 Human Sf9 insect cells
    The Ku70, a single-stranded DNA-dependent ATP-dependent helicase, is pivotal in DNA non-homologous end joining (NHEJ), central to double-strand break repair and V(D)J recombination. Operating as a DNA helicase II complex with a cell cycle-dependent preference for double-stranded DNA fork-like ends in the 3'-5' direction, it recognizes and binds to broken DNA ends during NHEJ, protecting them from resection. As a DNA-PK regulatory subunit, it enhances PRKDC's affinity to DNA, stabilizes broken DNA ends, and facilitates ligation in NHEJ. The heterodimer may act as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase) near double-strand breaks. Beyond DNA repair, it regulates transcription, osteocalcin expression, early ribosome assembly steps, and forms complexes involved in the innate immune response, showcasing its multifaceted cellular functions. Ku70-Ku80 Heterodimer Protein, Human (sf9, His) is a recombinant protein dimer complex containing human-derived Ku70-Ku80 Heterodimer protein, expressed by Sf9 insect cells, with N-His labeled tag. Ku70-Ku80 Heterodimer Protein, Human (sf9, His), has molecular weight of ~70 & 85 kDa, respectively.
  • HY-P7895
    Clusterin/APOJ Protein, Human (HEK293, His)

    rHuClusterin/APOJ, His ; Clusterin; Aging-Associated Gene 4 Protein; Apolipoprotein J; Apo-J; Complement Cytolysis Inhibitor; CLI; Complement-Associated Protein SP-40; Ku70-Binding Protein 1; NA1/NA2; Testosterone-Repressed Prostate Message 2; TRPM-2; CLU; APOJ; CLI; KuB1

    		 Human HEK293
    Clusterin/APOJ Protein, Human (HEK 293, His) expresses in HEK 293 cells with a His tag at the N-terminus. Clusterin (CLU) is a multifunctional glycoprotein that has been implicated in several physiological and pathological states, including Alzheimer’s disease (AD).

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